Estimation of gestational age-specific reference intervals for coagulation assays in a neonatal intensive care unit using real-world data.

Background: Interpretation of coagulation testing in neonates currently relies on reference intervals (RIs) defined from older patient cohorts. Direct RI studies are difficult, but indirect estimation may allow us to infer normative neonatal distributions from routinely collected clinical data.

Objective: Assess the utility of indirect reference interval methods in estimating coagulation reference intervals in critically ill neonates.