Publications by authors named "Carlotta Pastorino"

Article Synopsis
  • - A-DRESS (Allopurinol-induced Drug Reaction with Eosinophilia and Systemic Symptoms) is more common in adults but rare in children, with a case reported in a 16-year-old male with a severe reaction, including fever, rash, shock, and eosinophilia.
  • - The patient's condition improved after stopping allopurinol and receiving treatment with intravenous immunoglobulins (IVIG) and corticosteroids, highlighting the importance of quick intervention.
  • - This case emphasizes the need for early diagnosis of DRESS in pediatric patients and suggests that IVIG may play a significant role in their treatment.
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Corticophobia, fear of applying topical corticosteroids (TCSs), is a rising issue in industrialized countries, despite the actual safety of TCSs for atopic dermatitis (AD). Patients attending the Pediatric Dermatology Unit for skin examination were screened for AD. AD patients were included, and data were collected.

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Introduction: Spitzoid lesions are a wide tumour class comprising Spitz nevus (SN), atypical Spitz tumour (AST) and Spitz melanoma (SM).

Materials And Methods: We conducted a single-centre-based retrospective survey on all histologically diagnosed spitzoid lesions of paediatric patients (1-18 years) of the last 10 years (2012-2022). Histopathological reports and electronic records of patients were used to retrieve relevant data regarding patients' features, clinical and dermatoscopical aspects of lesions when recorded, and FISH tests when present.

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Anogenital warts (AWs) represent a therapeutic challenge, especially in infants, due to sensitive skin and frequent disease recurrence. Though the initial wait-and-see approach is often adopted in asymptomatic immunocompetent children, with spontaneous clearing in almost 90% of cases within two years, persistent or symptomatic lesions can be reasonably treated. However, few studies have been conducted on children.

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  • The study investigates the dermatological manifestations of COVID-19 in children, particularly noting the prevalence of chilblain-like lesions among infected and non-infected patients, attributed to a pronounced interferon response in younger individuals.
  • Conducted over six months, the research involved 137 patients aged 1 to 18 from 23 Italian dermatological units, who exhibited a variety of skin lesions primarily on the feet.
  • Results showed diverse skin symptoms, with many experiencing concomitant systemic symptoms, highlighting the complex interplay of dermatological and respiratory issues related to COVID-19 in children.
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  • - A study analyzed antibiotic susceptibility in 1833 strains from skin lesions at an Italian hospital, revealing variations in resistance between outpatients and inpatients! - Methicillin resistance was found more often in outpatients (18%) compared to inpatients (14%), and outpatients also had higher resistance to cotrimoxazole (8% vs. 4.1%)! - Overall, resistance to ampicillin was extremely high (99%) in both groups, while fusidic acid had the lowest resistance rate (3%), indicating challenges in treating pediatric skin infections in outpatient settings!
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Cutaneous mucinoses are a complex and diverse group of connective tissue disorders characterized by the accumulation of mucin and/or glycosaminoglycan in the skin and adnexa. Cutaneous focal mucinosis appears as a solitary, asymptomatic, skin-colored to white papule, nodule, or plaque located anywhere on the body or in the oral cavity. It presents mainly in adults and is characterized on histopathology by mucin throughout the upper and mid dermis.

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Spark's nevus is a particular type of melanocytic nevus that on histology shows features of both Spitz's and Clark's nevus. Clinically, it is an asymmetric, irregular, multicolored, pigmented lesion that is not clearly distinguishable from melanoma or dysplastic (Clark's) nevus. Dermoscopic features have not been described yet, and one could speculate that they are similar to those of Clark's nevi because the histopathologic architecture of Spark's nevus is similar to that of a Clark's nevus, resembling Spitz's nevi in the epithelioid morphology of melanocytes.

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Article Synopsis
  • Multinucleate cell angiohistiocytoma (MCA) is a rare, benign tumor that appears similar to other soft-tissue growths, making it sometimes difficult to diagnose.
  • This case study reports a solitary MCA found on the lower lip of a 46-year-old woman.
  • The findings suggest that healthcare professionals should include MCA in the differential diagnosis when evaluating oral soft-tissue lesions.
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