Publications by authors named "Carlotta Foletti"
Angew Chem Int Ed Engl
June 2018
Article Synopsis
- c-di-GMP is a key second messenger in bacteria that controls critical functions like biofilm formation and virulence, making it a prime target for combating infections.
- Researchers identified a specific tetrapeptide, Gup-Gup-Nap-Arg, that selectively binds to c-di-GMP in water through screening of a combinatorial peptide library.
- Further studies revealed that this tetrapeptide effectively inhibits biofilm growth in the pathogen P. aeruginosa and led to the design of a stronger-binding pentapeptide.
