Publications by authors named "Carlotta Difrancesco"
Article Synopsis
- Several studies indicate that sialylation, particularly through the deregulation of sialidases like NEU3, plays a crucial role in cancer progression, especially in colorectal cancer (CRC).
- NEU3 is often found to be overactive in CRC and interacts with the epidermal growth factor receptor (EGFR), which is a target for new cancer therapies.
- Research showed that active NEU3 enhances EGFR activation by desialylating it, affecting its phosphorylation status without altering its overall expression levels.
