Publications by authors named "Carlota Creus"
Satellite cells (SCs), muscle stem cells, display functional heterogeneity, and dramatic changes linked to their regenerative capabilities are associated with muscle-wasting diseases. SC behavior is related to endogenous expression of the myogenic transcription factor MYF5 and the propensity to enter into the cell cycle. Here, we report a role for miR-106b reinforcing MYF5 inhibition and blocking cell proliferation in a subset of highly quiescent SC population.
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- Late onset Pompe disease (LOPD) leads to gradual weakness in skeletal and respiratory muscles, which is treated with enzyme replacement therapy (ERT) using alglucosidase alpha (rhGAA).
- In a study of 25 ERT-treated patients, 72% developed antibodies against rhGAA, but their impact on clinical progression was examined with muscle function tests, spirometry, and quantitative MRI over one year.
- Results showed that low and intermediate antibody levels did not significantly affect muscle function, breathing tests, or MRI outcomes, suggesting these antibodies may not hinder the effectiveness of the treatment.
Duchenne muscular dystrophy (DMD), one of the most lethal genetic disorders, involves progressive muscle degeneration resulting from the absence of DYSTROPHIN. Lack of DYSTROPHIN expression in DMD has critical consequences in muscle satellite stem cells including a reduced capacity to generate myogenic precursors. Here, we demonstrate that the c-isoform of PITX2 transcription factor modifies the myogenic potential of dystrophic-deficient satellite cells.
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