Publications by authors named "Carlos da Costa"

Article Synopsis
  • The study investigates how genetic variations in the TLR7 gene impact responses to HTLV-1 infection, focusing on cytokine production and disease symptoms.
  • Researchers analyzed blood samples from HTLV-1 infected individuals, including those with inflammatory diseases and asymptomatic cases, alongside controls, using techniques like PCR and ELISA.
  • Findings indicated that specific genetic variations (polymorphisms) affect levels of immune responses, with some variants linked to higher levels of antiviral activity, though they did not correlate with disease symptoms.
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Considered the symbol fruit of the Brazilian Cerrado, pequi (Caryocar brasiliense Camb.) is an exotic and much-appreciated fruit with an internal mesocarp (edible part) with an eye-catching golden yellow color. In an unprecedented way, this study characterized the proteome throughout pequi development.

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Context: Saturated fats found in diets known as high-fat, cafeteria, or Western diets appear to have a negative effect on bone structure; however, few studies have focused on investigating this association, and the data available in the literature remain controversial.

Objective: The aim of the current review was to investigate the effects of a high-fat dietary intake on the bone structure of Wistar rats.

Data Sources: A search for articles was carried out in the Pubmed/MEDLINE, Web of Science, Embase, and Scopus databases.

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Article Synopsis
  • Human T lymphotropic virus 1 (HTLV-1) is linked to inflammatory diseases like HTLV-1-associated myelopathy (HAM), and genetic factors may influence how these diseases develop.
  • The study focuses on a specific genetic variation (rs2232365) in the promoter region of the FOXP3 gene, which is important for regulating immune responses and may affect the severity of inflammatory disorders like HAM.
  • Researchers analyzed DNA samples from asymptomatic carriers, HAM patients, and controls, finding that certain genotypes were associated with higher proviral loads, CD4 T cell counts, and inflammatory markers in those with HAM.
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The human T-lymphotropic virus type 1 (HTLV-1), isolated in 1980, causes T-cell leukemia/lymphoma in adulthood, a type of lymphoproliferative disease, and chronic HTLV-1-associated myelopathy, a disease that causes paralysis of the lower limbs, which occur in about 5% of cases in this viral infection. This study aimed to establish the hematological profile of patients with HTLV-1 infection in Belém do Pará, describing the hematological parameters under study, estimating the frequency of lymphocytic atypical, and associating the hematological profile with diseases and symptoms. Hematologic data from 202 individuals were analyzed, including 87 HTLV-1 infected individuals and 115 non-HTLV-1 infected individuals as a control group, composed, at a great part, of relatives of the infected.

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The interaction of copaiba oil in the polymer matrix of chitosan can produce a favorable synergistic effect and potentiate properties. Indeed, the bioactive principles present in copaiba oil have anti-inflammatory and healing action. In the present work, chitosan membranes containing different contents of copaiba oil copaíba (0.

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Background: Flaxseed oil (FO) is an alpha linolenic acid source important for growth and body development. However, there is little literature on the role of FO in critical stages of bone development and formation.

Objective: This study evaluated the influence of a diet containing FO on rat femurs.

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Full waveform inversion is an advantageous technique for obtaining high-resolution subsurface information. In the petroleum industry, mainly in reservoir characterisation, it is common to use information from wells as previous information to decrease the ambiguity of the obtained results. For this, we propose adding a relative entropy term to the formalism of the full waveform inversion.

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Article Synopsis
  • Human T-lymphotropic virus 1 (HTLV-1) is linked to a chronic neurodegenerative disease called HAM/TSP, and the study investigates the role of the anti-inflammatory protein Annexin A1 (AnxA1) in this condition.
  • The research involved 37 HTLV-1 infected individuals, comparing gene expression and plasma levels of AnxA1 among asymptomatic carriers, HAM/TSP patients, and a control group.
  • Findings indicate that while AnxA1 levels were higher in asymptomatic carriers compared to HAM/TSP patients, there are potential prognostic implications suggesting that measuring AnxA1 alongside proviral load could better predict disease progression in HTLV-1 related conditions.
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Hypercaloric low-protein diet may lead to a state of malnutrition found in the low-income population of Northeastern Brazil. Although malnutrition during critical periods in the early life is associated with cardiovascular diseases in adulthood, the mechanisms of cardiac dysfunction are still unclear. Here we studied the effects of post-weaning malnutrition due to low protein intake induced by a regional basic diet on the cardiac contractility of young adult rats.

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Full-waveform inversion (FWI) is a powerful technique to obtain high-resolution subsurface models, from seismic data. However, FWI is an ill-posed problem, which means that the solution is not unique, and therefore the expert use of the information is required to mitigate the FWI ill-posedness, especially when wide-aperture seismic acquisitions are considered. In this way, we investigate the multiscale frequency-domain FWI by using a weighting operator according to the distances between each source-receiver pair.

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Consumption of saturated fat causes deleterious effects on health, which could be minimized through physical activity and foods with functional characteristics consumption. The aim of the study was to evaluate the beverage rich in resveratrol consumption and physical exercise in gut microbiota, body composition, lipid peroxidation, interleukin-6 (IL6) concentration and systolic blood pressure (SBP) of rats to the high-fat diet. Wistar rats were fed with control diet, high-fat diet (HFD), HFD and 15 mL solution of resveratrol, HFD and 15 mL of grape juice, HFD and 10 mL of red wine.

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In this work, a novel methodology for tuning fractional order controller, so-called fractional order pole placement (FOPP) is proposed. The proposed methodology extends classical (integer order) pole placement technique, using commensurable transfer functions for representing fractional order controllers and placing the fractional dominant poles within an extended stability region based on three terms fractional transfer functions. The designed fractional order controller can be digitally implemented by using the Oustaloup integer approximation of the fractional order dynamics with Hankel model reduction.

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Article Synopsis
  • - HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive disease linked to inflammation in the central nervous system, where HTLV-1-infected T cells enhance their migration by altering adhesion receptor expression.
  • - The study examined the presence of three specific integrin alpha chains on T cells in both HAM/TSP patients and asymptomatic individuals, finding increased levels of CD49dhi CD4+ and CD49dhi CD8+ T cells in those infected with HTLV-1.
  • - The results indicate that elevated CD49d expression on T lymphocytes may play a role in disease development, suggesting that targeting CD49d could potentially prevent the migration of
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Acai seed was used herein as an Amazon biomass waste for the synthesis of activated and modified carbon in order to find a possible use for the large volume of residues generated during the processing of this fruit and to add value to this residue. Activated carbon materials were used to remove Pb, Fe, and Mg metal ions from water. The efficiency of removal of these ions by the acai seed activated carbon was compared with that by commercial activated carbon.

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Article Synopsis
  • SAMHD1 is a host enzyme that limits the availability of nucleotides for retroviruses like HTLV-1, potentially affecting how infections progress.
  • A study involving 108 HTLV-1 infected individuals examined the impact of genetic variations, specifically polymorphism rs6029941, on infection outcomes, but found no link to susceptibility or symptoms.
  • However, symptomatic patients carrying the G allele had higher levels of viral load and lower IFN-α, suggesting that this polymorphism could contribute to the development of disease symptoms.
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Introduction: Chronic hyperglycemia is caused by diabetes mellitus-committed genital morphophysiology, and oxidative stress is one of the main factors involved in this process. Alpha lipoic acid (ALA) can prevent metabolic and morphological changes in diabetic individuals.

Objectives: In present study, we evaluated the effects of regular ALA consumption on the spermatogenesis and histoarchitecture in the male genital system of diabetic rats.

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Article Synopsis
  • HTLV-1, a virus affecting 2-5 million people globally, is linked to various diseases and has genetically stable envelope glycoproteins (gp), particularly the gp46 gene, which impacts infectivity and immune response.
  • A study in Belém, Brazil, analyzed 40 HTLV-1 patients over five years, finding that most were symptomatic and carried a common genotype with low mutation rates, indicating genetic stability.
  • Notably, 66.6% of symptomatic patients had amino acid mutations, with a new mutation (N93D) linked to symptomatic cases, highlighting potential implications for disease management.
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Article Synopsis
  • HTLV-1 infection is linked to adult T-cell leukemia (ATL) and other inflammatory diseases, but it is often overlooked in health discussions.
  • Originally seen as isolated cases, it has been observed that HTLV-1-related diseases can occur in clusters within families, leading to questions about the causes.
  • This study introduces a notable family cluster of HTLV-1 cases spanning three generations, suggesting a possible connection to the FAS -670A/G genetic variation.
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Study evaluates testis mass in rats subjected to early weaning and subsequently nourished with diet containing flour or flaxseed oil. Pups were weaned for separation from mothers at 14 days (early weaning, EW) and 21 days (control, C). After 21 days, the control group (C60) was nourished with control diet.

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During cardiac failure, cardiomyocytes have difficulty in using the substrates to produce energy. L-carnitine is a necessary nutrient for the transport of fatty acids that are required for generating energy. Coronary artery graft surgery reduces the plasma levels of L-carnitine and increases the oxidative stress.

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In women, bone mass undergoes changes during pregnancy and the postpartum period, which has a risk for subsequent development of osteoporosis. Thus, the present study aims to evaluate the effects of flaxseed flour in femur quality during post-weaning of dam rats. After weaning, the rats were divided into control (C, n = 7) and experimental (F, n = 7) groups treated with a diet containing 25 g of flaxseed flour in the lactating period and 15 g in the maintenance period.

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Flaxseed oil is an alpha linolenic acid source important in the growth and body development stage; furthermore, this acid acts on adipose tissue and bone health. The aim of this study was to evaluate body composition, fatty acid composition, hormone profile, retroperitoneal adipocyte area and femur structure of pups at weaning, whose mothers were fed a diet containing flaxseed oil during lactation. After birth, pups were randomly assigned: control (C, n = 12) and flaxseed oil (FO, n = 12), rats whose mothers were treated with diet containing soybean or flaxseed oil.

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The aim of this study was to analyze whether flaxseed flour or flaxseed oil treatment contributes to femoral structure in male rats subjected to early weaning. Pups were weaned for separation from mothers at 14 days (early weaning, EW) or 21 days (control, C). After 21 days, the control (C60) was fed with the control diet.

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Purpose: This study aimed to quantitatively and qualitatively evaluate the effects of a flaxseed-based diet on the histoarchitecture of the prostate of normal Wistar rats and of rats with induced BPH.

Methods: The study included four experimental groups of ten animals each: casein control group (CCG), who were fed a casein-based diet; flaxseed control group (FCG), who were fed a flaxseed-based diet; hyperplasia-induced casein group (HICG), who were fed a casein-based diet; and hyperplasia-induced flaxseed group (HIFG), who were fed a flaxseed-based diet. Hyperplasia was induced by the subcutaneous implantation of silicone pellets containing testosterone propionate.

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