Contribution of Stroke to Long-Term All-Cause and Cause-Specific Mortality in Mexico City.

Background And Objectives: Stroke mortality is more common in low-income and middle-income nations such as Mexico. Prognosis data typically rely on short-term hospital follow-ups, revealing high mortality rates due to systemic complications and early recurrence. We aim to explore stroke's long-term impact by examining all-cause and cause-specific mortality.

Clinical predictors for mechanical ventilation assistance in Guillain-Barré syndrome.

Background: Guillain-Barré syndrome (GBS) frequently leads to respiratory failure and autonomic dysfunction, resulting in approximately one-third of patients requiring mechanical ventilation.

Objective: This study aimed to identify clinical predictors for mechanical ventilation in patients with GBS.

Methods: This research was conducted from 2010 to 2021 using registries from a tertiary hospital in an upper middle-income Latin American country.

Yerbamate Tea Consumption: A Protective Factor in Parkinson Disease.

Introduction: Little is known about the association between Yerbamate (YMT) tea consumption and Parkinson disease (PD). We determined whether there was an association between YMT tea consumption and PD.

Methods: We conducted a multicenter case-control study in 3 countries (Argentina, Paraguay, and Uruguay).

Spastic Paraplegia Type 7 and Movement Disorders: Beyond the Spastic Paraplegia.

Background: Spastic paraplegia type 7 (SPG7) mutations can present either as a pure form or a complex phenotype with movement disorders.

Objective: Describe the main features of subjects with SPG7 mutations associated with movement disorders.

Methods: We analyzed the clinical and paraclinical information of subjects with SPG7 mutations associated with movement disorders.

Adherence to treatment in Parkinson's disease: A multicenter exploratory study with patients from six Latin American countries.

Background: Adherence to treatment in Parkinson's disease (PD) is compromised due to the need for multiple therapies, comorbidities related to aging, and the complexity of therapeutic schemes. In the present study, we aimed to explore adherence to treatment in groups of PD patients from six Latin-American (LA) countries and identify its associated demographic and clinical parameters.

Methods: A multicenter, cross-sectional, exploratory study was conducted from September 2016 to March 2017.

Aripiprazole in Meige Syndrome: Clinical Response and Implications for Treatment Development.

Introduction: Meige syndrome is a segmental form of dystonia where botulinum toxins are the preferred treatment option. However, its invasive nature, treatment costs, partial responsiveness, and benefit duration are some of their limitations.

Methods: Six consecutive subjects with Meige syndrome were treated only with aripiprazole.

Functional Dyskinesias following Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease: A Report of Three Cases.

Background: Functional (psychogenic) dyskinesias in patients with Parkinson's disease (PD) are exceedingly rare.

Cases: Herein we report three patients with PD who presented with functional dyskinesias in the first 3 months after subthalamic nucleus deep brain stimulation (DBS). All patients presented with chorea mimicking levodopa or stimulation-induced dyskinesias in the first 24 hours following stimulation adjustment.

Successful Unilateral Surgical Approach to Internal Globus Pallidus and Ventral Intermediate Nucleus of the Thalamus in 3 Cases of Myoclonus-Dystonia Syndrome.

Surgical approaches of internal globus pallidus (GPi) and ventral intermediate thalamic nucleus (Vim) have been used to treat different movement disorders. Three subjects with myoclonus-dystonia syndrome were surgically treated, one of them with GPi and Vim stimulation, while radiofrequency ablation of these structures was performed in the other 2 subjects. Surgical approach of both targets was performed simultaneously on each subject.

Generalized Dystonia and Paroxysmal Dystonic Attacks due to a Novel Variant.

Background: Paroxysmal movement disorders are a heterogeneous group of neurological diseases, better understood in recent years thanks to widely available genetic testing.

Case Report: A pair of monozygotic twins with dystonia and paroxysmal attacks, resembling paroxysmal non-kinesigenic dyskinesias, due to a novel variant are reported. The complete resolution of their paroxysms was achieved using levodopa and deep brain stimulation of the internal globus pallidus.

The Spectrum of Acute Disseminated Encephalomyelitis and Mild Encephalopathy with Reversible Splenial Lesion.

Background: Acute disseminated encephalomyelitis and mild encephalopathy with reversible splenial lesion are autoimmune demyelinating disorders of central nervous system. Diagnosis remains clinical, aided by neuroimaging confirmation and excluding other causes. In the absence of a biological marker, the diagnosis of these entities based on clinical and imaging criteria could overlap.

Blepharospasm as a Manifestation of Peak of Dose Dyskinesia in Parkinson Disease.

Objectives: The aim of the study was to report 4 patients with Parkinson disease (PD) and On-period blepharospasm (BS).

Methods: We analyzed patients with PD and motor fluctuations who developed BS in several different centers in Latin America.

Results: Four patients had BS while in the ON periods.

Beyond dystonia and ataxia: Expanding the phenotype of SQSTM1 mutations.

Background: Homozygous sequestomosome-1 gene mutations have been recently linked to neurodegeneration with dystonia, ataxia and gaze palsy. Seven affected families were identified thus far.

Objective: To describe four new cases with additional phenotypical features.

Allergy to Carbidopa.

Background: D-Decarboxylase inhibitors, such as carbidopa or benserazide, have been used as adjunct therapy in Parkinson disease shortly after levodopa synthesis in the 1960s. These compounds increase intracerebral drug concentration and decrease adverse effects by blocking peripheral conversion to dopamine. Skin rash as part of an allergic reaction was previously described in subjects who were using levodopa in combination with carbidopa or benserazide; however, etiology was never clear.

Autosomal dominant leukodystrophy presenting as Alzheimer's-type dementia.

Autosomal dominant leukodystrophy is a neurodegenerative disorder caused by either point mutations or duplication of the lamin B1 gene on chromosome 5q23. The typical clinical picture consists of autonomic symptoms as well as cerebellar and pyramidal signs. Here we present the case of a 57-year-old female referred to our clinic due to cognitive decline.

Successful Treatment of Brachial Plexopathy Due to Herpes Zoster Infection With Intravenous Immunoglobulin.

Objective: The aim of this study was to report the case of a male patient with Parkinson disease who developed brachial plexopathy (BP) due to varicella-zoster virus, which was successfully treated with human immunoglobulin.

Method: We report the case of a 75-year-old male subject with a diagnosis of Parkinson disease who came to our hospital complaining of pain, skin lesions, and strength loss in his right arm during the past 2 months. Physical examination revealed vesicular rash compatible with varicella-zoster virus lesions.

Holmes tremor: Clinical description, lesion localization, and treatment in a series of 29 cases.

Objective: To describe the clinical features, etiology, findings from neuroimaging, and treatment results in a series of 29 patients with Holmes tremor (HT).

Methods: A retrospective study was performed based on review of medical records and videos of patients with HT diagnosis.

Results: A total of 16 women and 13 men were included.

Self-Perceived Pre-Motor Symptoms Load in Patients with Parkinson's Disease: A Retrospective Study.

Background: Parkinson's disease is characterized by motor and non-motor clinical features. The latter may present as pre-motor symptoms several years before the motor onset.

Objective: To analyze the association between pre-motor symptoms load and its lead-time in relation to the motor onset and time to diagnosis.

Impact of Neuropsychiatric Symptoms on the Quality of Life of Subjects with Parkinson's Disease.

Background: Neuropsychiatric symptoms in Parkinson's disease (PD) are frequent. Impact of neuropsychiatric symptoms on quality of life has recently become a relevant topic of research due to its potential to develop targeted therapies to improve quality of life.

Objective: To determine the impact of neuropsychiatric symptoms in patients with PD using the Parkinson's Disease Questionnaire Short Form (PDQ-8).

Convergent validation of EQ-5D-5L in patients with Parkinson's disease.

Introduction: The European Quality of Life Questionnaire 5 level version (EQ-5D-5L) is a recently updated instrument to assess Health-Related Quality of Life (HRQoL) that has not been validated extensively. The main objective of this study was to evaluate the internal consistency and convergent validation of the EQ-5D-5L in a large sample of subjects with Parkinson's disease (PD).

Methods: A cross-sectional study was carried out.

[Time from motor symptoms onset to diagnosis of Parkinson's disease in Mexico].

Introduction: Parkinson's disease is characterized by a wide spectrum of motor and non-motor symptoms with an insidious onset. Identification of these symptoms by the patient as well as by the physician is determinant in order to achieve an early diagnosis.

Objective: To determine the time from motor symptoms onset to the diagnosis of Parkinson's disease and analyze the clinical and demographic factors related to it.

[Profile characterization of Parkinson's disease in Mexico: ReMePARK study].

Introduction: The Mexican Registry of Parkinson´s disease (ReMePARK) is nested within a multicentric cohort aimed to describe motor, non-motor, and genetic determinants of Parkinson's disease in Mexican patients.

Material And Methods: To date, clinical and demographic data from 1,083 subjects has been obtained. Here we present the demographic and clinical data of the current sample along with its comparison with international reports.