Effect of eccentric action velocity on expression of genes related to myostatin signaling pathway in human skeletal muscle.

The aim of this study was to investigate the effects of an acute bout of eccentric actions, performed at fast velocity (210ºs) and at slow velocity (20ºs), on the gene expression of regulatory components of the myostatin (MSTN) signalling pathway. Participants performed an acute bout of eccentric actions at either a slow or a fast velocity. Muscle biopsy samples were taken before, immediately after, and 2 h after the exercise bout.

Effect of eccentric exercise velocity on akt/mtor/p70(s6k) signaling in human skeletal muscle.

It has been suggested that muscle tension plays a major role in the activation of intracellular pathways for skeletal muscle hypertrophy via an increase in mechano growth factor (MGF) and other downstream targets. Eccentric exercise (EE) imposes a greater amount of tension on the active muscle. In particular, high-speed EE seems to exert an additional effect on muscle tension and, thus, on muscle hypertrophy.