Publications by authors named "Carlos Toscano-Ochoa"
Processing time-dependent information requires cells to quantify the duration of past regulatory events and program the time span of future signals. At the single-cell level, timer mechanisms can be implemented with genetic circuits. However, such systems are difficult to implement in single cells due to saturation in molecular components and stochasticity in the limited intracellular space.
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- Autoregulatory feedback loops are crucial for regulating various molecules, with negative loops enhancing system robustness and positive loops facilitating cell state transitions.
- Recent studies suggest many novel feedback loops, but current methods struggle to detect all regulatory interactions and their dynamics.
- This research presents a new mathematical and experimental approach for identifying and quantifying feedback loops, specifically through RNA binding proteins in yeast, revealing insights into their regulatory roles and the effect of synthetic feedback constructions.