Publications by authors named "Carlos Torrijos Pulpon"

Article Synopsis
  • - This study examines how inflammation in chondrogenic cells affects rat and mouse glial cell lines, particularly focusing on the role of nitric oxide (NO) in their communication.
  • - Researchers used a transwell system to coculture inflamed ATDC5 cells with GL261 or C6 glioma cells, measuring cell viability and gene expression changes.
  • - Findings reveal that NO from chondrocytes enhances inflammatory signals in glial cells via specific signaling pathways (ERK1/2 and AKT), suggesting a link between cartilage inflammation and neuroinflammation in conditions like osteoarthritis.
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Article Synopsis
  • Obesity increases the risk of chronic diseases like osteoarthritis (OA) and rheumatoid arthritis (RA), with adipose tissue functioning as an endocrine organ that releases adipokines, including LCN2, which affect inflammation and immunity.* -
  • The study measured LCN2 serum levels in healthy individuals, OA, and RA patients using different treatment methods (conventional treatment and adalimumab), finding elevated LCN2 levels in both OA and RA patients.* -
  • The results indicate that LCN2 levels correlate with various inflammatory markers, particularly in RA patients on conventional treatment, suggesting that LCN2 could serve as an additional biomarker for inflammation in rheumatic diseases.*
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Article Synopsis
  • Legg Calve Perthes disease (LCPD) is a childhood hip disorder caused by reduced blood flow, leading to femoral head deformity if not treated.
  • This study investigated four pelvic radiographic parameters to see if they can predict outcomes in LCPD patients, comparing data from healthy vs. affected hips.
  • Significant differences were found in three parameters, but only the Acetabular Depth-Width Ratio was predictive of disease outcomes, highlighting the need for more extensive research.
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Adipokines are a heterogeneous group of signalling molecules secreted prevalently by adipose tissue. Initially considered as regulators of energy metabolism and appetite, adipokines have been recognized for their substantial involvement in musculoskeletal disorders, including osteoarthritis, rheumatoid arthritis, and many others. Understanding the role of adipokines in rheumatic inflammatory and autoimmune diseases, as well as in other musculoskeletal diseases such as intervertebral disc degeneration, is crucial for the development of novel therapeutic strategies.

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Here, we present the synthesis of a series of chemical homopolymeric and copolymeric injectable hydrogels based on polyethylene glycol methyl ether methacrylate (PEGMEM) alone or with 2-dimethylamino ethyl methacrylate (DMAEM). The objective of this study was to investigate how the modification of hydrogel components influences the swelling, rheological attributes, and in vitro biocompatibility of the hydrogels. The hydrogels' networks were formed via free radical polymerization, as assured by H nuclear magnetic resonance spectroscopy (H NMR).

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Background: The Mediterranean diet is linked to various health benefits, especially the consumption of olive oil as a key component. Multiple studies highlight its advantages, particularly due to its fatty acid composition and additional components like phenolic compounds. A significant antioxidant compound, oleocanthal, known for its antioxidant properties, has gained attention in the pharmaceutical industry for its anti-inflammatory and antiproliferative effects.

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