Publications by authors named "Carlos T Schmidt-Cerski"
It is known that the inflammation process leading to oxidative stress and thyroid hormone metabolism dysfunction is highly altered in metabolic dysfunction associated with steatotic liver disease (MASLD). This study aims to address the effect of ornithine aspartate (LOLA) and vitamin E (VitE) in improving these processes. Adult Sprague-Dawley rats were assigned to five groups and treated for 28 weeks: controls ( = 10) received a standard diet (for 28 weeks) plus gavage with distilled water (DW) from weeks 16 to 28.
View Article and Find Full Text PDFObjective: The study aimed to assess the role of TE in HIV-infected patients with NAFLD.
Methods: HIV-infected patients undergoing ART were enrolled between August 2016 and February 2017, following the inclusion criteria: ≥18 years with undetectable HIV viral load. Exclusion criteria included pregnancy, alcohol intake ≥20g/day and co-infection with hepatitis B or C.
Chronic liver disease is an important cause of morbidity and mortality among people living with human immunodeficiency virus (HIV) and is frequently related to non-alcoholic fatty liver disease (NAFLD). The objective is to estimate the prevalence and risk factors of hepatic steatosis among consecutive patients with stable HIV infection on antiretroviral therapy (ART). Also, the use of transient elastography (TE) as a mean to identify a subgroup at risk for non-alcoholic steatohepatitis (NASH) and/or liver fibrosis.
View Article and Find Full Text PDFArticle Synopsis
- Topical hypothermia (TH) and ischemic preconditioning (IPC) are both strategies investigated for their effectiveness in reducing inflammation and injury caused by ischemia/reperfusion (I/R) in the liver.
- In a study with Wistar rats, TH significantly lowered pro-inflammatory markers while increasing anti-inflammatory markers compared to normothermic ischemia (NI), and TH alone proved more protective than isolated IPC.
- The combination of TH and IPC provided similar benefits to TH alone but did not offer any additional protective effects, specifically in minimizing inflammatory processes.
Introduction: Considering the high prevalence of liver tumors and the impact on patient survival, a greater understanding of the biological behavior of those tumors if of great importance. The multidrug resistance gene (MDR1) may present as single nucleotide polymorphism (SNP) which can affect the expression and activity of P-glycoprotein (Pgp), and high expression of Pgp has been associated with a worse prognosis in affected patients.
Objective: To correlate the C3435T polymorphism in the MDR1 gene with the immunohistochemical expression of Pgp.