Publications by authors named "Carlos Serrano-Reyes"
Background: Drug hypersensitivity reactions (DHRs) have a significant impact on both, patient and their treating physicians; it is considered a public health concern. The history of allergy to drugs, limits therapeutic options and will lead to the use of more expensive and potentially less effective options. Drug desensitization (DD) is considered as a procedure with a positive impact on the prognosis of the patient's disease.
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- Chronic urticaria (CU) is frequently managed with Omalizumab in cases where antihistamines are ineffective, but little research has focused on its use in Latin America, particularly in Colombia.
- A study was conducted with 123 patients in Colombia from 2014 to 2017, primarily consisting of women (73.1%) with an average age of 47.1 years, where most patients were diagnosed with chronic spontaneous urticaria.
- Emotional factors such as anxiety and stress were significant among patients, with 34.9% reporting anxiety symptoms and 34.1% experiencing exacerbations due to stress, highlighting the psychological aspect of CU management.
Meloxicam and/or Etoricoxib Could Be Administered Safely in Two Equal Doses during an Open Oral Challenge in Patients with Nonsteroidal Anti-Inflammatory Drug Hypersensitivity.
Int Arch Allergy Immunol
September 2021
Background: Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) are common. These patients require an effective and safe analgesic alternative.
Objective: The aim of the study was to demonstrate the safety of meloxicam and etoricoxib administered by open oral challenge in 2 equal steps in patients with NSAID hypersensitivity.
Background: Evaluation of drug allergy is intricate because of nonstandardized testing and challenge method variability.
Objective: To determine the clinical and epidemiologic characteristics of a large group of patients with suspected drug allergies who underwent 1 or more provocation tests (PT), and to establish whether performing this test in fewer steps is safe and effective.
Methods: A cross-sectional descriptive study was conducted in patients with suspected drug allergies who underwent a provocation test at the allergy service of Fundación Valle del Lili, Cali, Colombia, from January 2011 to August 2017.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous adverse reactions to drugs. Granulysin (GNLY) plays a key role in keratinocyte apoptosis during SJS/TEN pathophysiology. To determine if GNLY-encoding mutations might be related to the protein's functional disturbances, contributing to SJS/TEN pathogenesis, we performed direct sequencing of GNLY's coding region in a group of 19 Colombian SJS/TEN patients.
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