Publications by authors named "Carlos S de Jesus"
Article Synopsis
- Monitoring genetic diversity and drug resistance mutations (DRMs) in HIV-1 is essential for understanding its epidemiology, particularly in a study of 42 HIV-positive pregnant women in Luanda, who had not yet begun antiretroviral therapy (ART).
- The research revealed a variety of HIV-1 subtypes, with subtype C being the most prevalent at 38%, and identified that 18% of the analyzed sequences contained DRMs, largely affecting non-nucleoside reverse transcriptase inhibitors.
- The findings highlight the importance of continuing to monitor HIV diversity and resistance to inform and potentially revise existing ART guidelines in Angola based on current data.
Background: Human immunodeficiency virus (HIV) drug resistance profiles are needed to optimize individual patient management and to develop treatment guidelines. Resistance profiles are not well defined among individuals on failing second-line antiretroviral therapy (ART) in low- and middle-income countries (LMIC).
Methods: Resistance genotypes were performed during screening for enrollment into a trial of third-line ART (AIDS Clinical Trials Group protocol 5288).
Introduction: The widespread use of antiretroviral therapy increased the transmission of antiretroviral resistant HIV strains. Antiretroviral therapy initiation during acute/recent HIV infection limits HIV reservoirs and improves immune response in HIV infected individuals. Transmitted drug resistance may jeopardize the early goals of early antiretroviral treatment among acute/recent HIV infected patients.
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