Publications by authors named "Carlos R Hermosilla"
Introduction: The two-humped Bactrian camel () is a large, even-toed ungulate native to the steppes of Central Asia. Domestic Bactrian camels are economically important in Mongolia and other Central Asian countries. These animals are used for transport, milk and meat production, and camel racing which is a great culture of nomads.
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- Bovine besnoitiosis is caused by a parasite and triggers neutrophil extracellular trap (NET) formation as an immune response, but the role of ATP in this process is not well understood.
- Research shows that exposure to tachyzoites doesn't affect overall ATP levels in bovine neutrophils but does enhance their oxygen consumption and leads to increased NET formation, particularly when ATPγS is added.
- The study identifies the P2X1 purinergic receptor as crucial for NET formation and neutrophil clustering in response to the parasite, while other purinergic receptors do not appear to influence this process.
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- Cryptosporidiosis, caused by an apicomplexan parasite, is a major diarrheal pathogen in calves and contributes to significant economic losses and health issues in both livestock and children.
- Neonatal bovine polymorphonuclear neutrophils (PMN) can form neutrophil extracellular traps (NETs) to combat this parasite, demonstrating their role in the innate immune response.
- This study reveals that neonatal bovine PMN's NETosis is triggered by the parasite and is dependent on the P2X1 receptor, suggesting its potential as a mechanism for controlling cryptosporidiosis.
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- The study focuses on a zoonotic parasite from the phylum Alveolata that causes cryptosporidiosis in humans and animals, highlighting the lack of effective treatments or vaccines.
- Researchers used advanced imaging techniques to identify and locate molecular biomarkers in infected host cells and calf intestines, finding over a thousand unique molecular signals, especially in infected samples.
- The results provide new insights into the metabolic changes associated with cryptosporidiosis, emphasizing its impact on vulnerable populations like children in developing countries.
The apicomplexan protozoan parasite is responsible for cryptosporidiosis, which is a zoonotic intestinal illness that affects newborn cattle, wild animals, and people all over the world. Mammalian monocytes are bone marrow-derived myeloid leukocytes with important defense effector functions in early host innate immunity due to their ATP purinergic-, CD14- and CD16-receptors, adhesion, migration and phagocytosis capacities, inflammatory, and anti-parasitic properties. The formation of monocyte extracellular traps (METs) has recently been reported as an additional effector mechanism against apicomplexan parasites.
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- The research highlights the first report of certain babesial infections in Indonesia, noting that these infections can persist after treatment, potentially allowing recovered cattle to spread the disease through tick vectors.
- The investigation also collected ticks from affected cattle, identifying a specific tick species as a likely vector, and emphasizes the need for increased farmer awareness and strategies for tick control to prevent disease spread in Java's busy livestock trade.
Background: Acute ruminal acidosis (ARA) is a metabolic disease of cattle characterized by an aseptic synovitis. ARA is the result of an increased intake of highly fermentable carbohydrates that frequently occurs in dairy cattle subjected to high production requirements. In human joint diseases such as rheumatoid arthritis and gout, several pro-inflammatory molecules are increased in the synovial fluid, including cytokines, prostaglandin E (PGE), metalloproteinases, and neutrophil extracellular traps (NETs).
View Article and Find Full Text PDFEimeria zuernii and E. bovis are host-specific apicomplexan parasites of cattle causing haemorrhagic typhlocolitis in young animals worldwide. During first merogony, both Eimeria species form giant macromeronts (>300 μm) in host endothelial cells containing >120,000 merozoites I in vivo.
View Article and Find Full Text PDFDuring first merogony Eimeria bovis forms large macromeronts in endothelial host cells containing >120 000 merozoites I. During multiplication, large amounts of cholesterol are indispensable for the enormous offspring membrane production. Cholesterol auxotrophy was proven for other apicomplexan parasites.
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