Recurrent thrombosis as a clinical presentation of Whipple disease.

Whipple's disease (WD) is a rare infectious disease with a wide clinical spectrum. Associated thrombotic manifestations are not well described in WD, only related to 'stroke-like syndrome'. We present a case of a 39-year-old man with a 1-year history of self-limited episodes of fever, associated with generalised adenopathies and recurrent superficial and deep venous thrombosis events, which have resorted four times despite the anticoagulant treatment.

Long-term follow-up of jaw osteomyelitis associated with bisphosphonate use in a tertiary-care center.

Objectives: This study reviews our experience in bisphosphonate-associated jaw osteomyelitis (BJOM), focusing on the incidence, etiology, treatment, and long-term outcome.

Methods: Retrospective review of the clinical histories adult patients diagnosed with BJOM (1995-2008) in a tertiary hospital.

Results: BJOM was found in 30 of 132 (22.

Bone and joint tuberculosis.

Introduction: Bone and joint tuberculosis has increased in the past two decades in relation with AIDS epidemics.

Material And Methods: A literature review of bone and joint tuberculosis, focusing on Pott's disease.

Results: Bone and joint TB comprises a group of serious infectious diseases whose incidence has increased in the past two decades, especially in underdeveloped countries, in part due to the AIDS epidemic.

Clinical experience with daptomycin for the treatment of patients with knee and hip periprosthetic joint infections.

Objectives: To investigate the clinical efficacy and safety of daptomycin in the treatment of hip and knee periprosthetic joint infections (PJIs).

Methods: We completed a retrospective review of all patients in our institution (n=20) who were treated with daptomycin for hip or knee PJI, over the 36 month period from January 2008 until December 2010.

Results: Infection types included eight cases with acute infections, nine cases of chronic infection and three cases of positive intraoperative cultures.

[Recurrent urinary tract infections].

Recurrent urinary tract infections (RUTI) are a frequent clinical problem in sexually active young women, pregnant or postmenopausal women and in patients with underlying urological abnormalities. The present chapter reviews RUTI based on their classification: relapses, which usually occur early (< 1 month), are caused by the same microorganism and are associated with underlying urological abnormalities, and reinfections, which usually occur later and are caused by a new distinct microorganism (or by the same microorganism usually located in the rectum or uroepithelial cells). The pathogenesis of RUTI is reviewed and the risk factors associated with RUTI in premenopausal women (usually related to sexual activity), postmenopausal women (in whom estrogen deficiency has a significant effect on the vaginal Lactobacillus flora), and in pregnant women are discussed.