Sickle Cell Trait Induces Oxidative Damage on Proteome at Erythrocyte Stages.

The presence of hemoglobin A-S (HbAS) in erythrocytes has been related to the high production of reactive oxygen species (ROS) and an increased in intracellular oxidative stress that affects the progress of erythrocytic cycle life and attenuates its serious clinical symptoms. Nevertheless, oxidative effects on proteome across the intraerythrocytic cycle in the presence of HbAS traits have not been described yet. Here, an immune dot-blot assay was used to quantify the carbonyl index (C.