Longitudinal assessment of SNPs rs72552763 and rs622342 in over HbA1c control among Mexican-Mestizo diabetic type 2 patients.

In Mexico, 75% of diabetes mellitus type 2 (DMT2) patients are not in glycaemic control criteria (HbA1c<7%); this entails a significantly variable drug response. Amongst the factors influencing such variability, are genetics, more specifically, single nucleotide polymorphisms (SNPs). Three genes implied in metformin pharmacokinetics are , , and , which are polymorphic.