Publications by authors named "Carlos Martinez-Sanchiz"
Introduction: The current challenge on renal cell carcinoma (RCC) is to finding a non-invasive biomarker for improving their diagnostic and therapeutic management. In the present study, we analyzed the clinical value of plasma levels of cell-free DNA (cfDNA) and RNA (cfRNA) of two genes: glyceraldehyde 3-phosphate-dehydrogenase (GAPDH) and human telomerase reverse transcriptase (hTERT).
Materials And Methods: We recruited 82 patients with RCC, and 20 healthy subjects.
Objective: In the Spanish health system, General Practitioners (GPs) play a key role in regulating the flow of patients to hospital care. Most of patients with BPH can be managed through out the evolution of the disease exclusively by the GPs. METHODS: A pre-experimental study was carried outin two periods, before (pre-test) and after (post-test) of the dissemination of a management protocol for patients with BPH.
View Article and Find Full Text PDFIntroduction: Elevated mRNA expression of human telomerase reverse transcriptase (hTERT mRNA) is common in many types of tumors, participating in tumor growth and progression. Such expression has not been sufficiently examined in renal cancer. The goal of the present study was to quantify it and analyze its possible clinical value in the management of this pathology.
View Article and Find Full Text PDFObjective: To describe the clinical presentation, preoperative diagnostic possibilities, and treatment of cystic nephroma.
Methods: We describe a case of cystic nephroma in an adult male and show that, both in our patient and in the literature, a definitive diagnosis can only be obtained postoperatively, even when there is a reasonable clinical suspicion.
Conclusions: Cystic nephroma is rare, and some authors consider it a questionable entity.
Objective: To describe a case of para-urethral leiomyoma and to review the literature.
Methods: The usual preoperative diagnostic procedures and clinical manifestations are discussed.
Results: The mass was resected and, 6 years later, the patient remains asymptomatic and with no recurrence.
Objective: To report a case of tubulocystic renal carcinoma diagnosed in an adult, after a work up study for hematuria.
Methods/results: 59-year-old male, CT scan was performed during a study for self-limited hematuria showing a 4.2 cm solid mass with areas suspicious of pseudocystic malignancy.
Objective: To present one case of adrenal ganglioneuroma incidentally diagnosed in an adult.
Methods/results: 44-year-old woman with a 2.3 cm incidentaloma in the left adrenal gland diagnosed by CT scan.
Vesical nephrogenic adenoma is a rare, benign entity that appears most commonly in middle-aged males. Its etiology is unknown, but it has been linked to chronic irritating factors, such as infection, trauma, urological surgery, kidney stones, foreign bodies and chemical agents, such as Bacille Calmette-Guerin. We report 2 new cases with a history of transurethral resection of the bladder and the prostate and a history of prolonged voiding symptoms.
View Article and Find Full Text PDFObjective: We present a case of X-Y translocation with male phenotype (46,XX testicular disorder of sex development) and review the literature.
Methods: Disorders of sex development with mismatch of genetic, gonadal and phenotypic sex are quite rare, and some are due to genetic or chromosomal abnormalities. The karyotype was investigated by a cytogenetic study of peripheral blood (phytohemagglutinin-timulated lymphocyte culture over 72 hours).
Objective: Remember that kidney cancer is a disease whose incidence is increasing due to increased use of additional imaging tests, which is changing the way of diagnosis, making the classic clinical syndrome synonymous with advanced illness.
Methods: We report the case of a patient with a right renal tumor with renal vein involvement that in the natural course of the disease showed a vaginal metastasis of clear renal cell carcinoma, which was treated with surgical excision.
Results: This case is a clear example of how unpredictable is the clinical evolution of this disease and how little we know about the way of dissemination.
Purpose: To estimate the prevalence and importance of GSTT1, GSTM1, and CYP1B1 genotypes in renal cell carcinoma (RCC), and to identify their value as a prognostic factor.
Materials And Methods: Cross-sectional study of a group of patients diagnosed with RCC (n = 133) and a control group (n = 208) with benign conditions and no history of tumor. Controls were selected by cumulative samples and mixed pairing.
Objective: To describe two cases of urothelial tumors in inguinoscrotal bladder hernias and comment on the low incidence of this condition.
Methods: Two patients were diagnosed and treated by partial cystectomy and hernia repair.
Results: The clinical outcome of both patients was good at two and three years, respectively, and neither patient experienced hernia or tumor recurrence.
Objectives: To investigate our case series of patients with primary retroperitoneal tumors over the past 10 years, analyzing clinical symptoms, diagnostic tests, tumor pathology, surgical data, concomitant cancer treatments, recurrence and survival rates.
Methods: Retrospective analysis of 37 patients with primary retroperitoneal tumors diagnosed at our hospital over the past 10 years.
Results: Computed tomography (CT) was the imaging technique used most often and the most accurate.
Objectives: To report 2 cases of median raphe cysts, 1 in the penis and the other in the perineum.
Method: Two cases of median raphe cyst are described; the first was treated by surgery and the second required no treatment.
Results: The surgical patient experienced no complications and was asymptomatic with no recurrence at 2 years.
Objective: To study and review spermatic cord sarcomas, including symptoms, diagnosis, and treatment.
Methods/results: We review the Spanish and international literature and report 4 new cases: 2 patients with well-differentiated spermatic cord liposarcomas (1 treated by simple tumorectomy), 1 patient with liposarcomatous degeneration of a previously excised atypical lipoma, and 1 patient operated for a malignant retroperitoneal fibrous histiocytoma with subsequent local recurrence in the paratesticular region.
Conclusions: Spermatic cord sarcomas are rare entities that usually appear as painless paratesticular mass.
Objectives: To evaluate the quality of life of patients with stress urinary incontinence (SUI) operated in the Department of Urology at the Complejo Hospitalario Universitario in Albacete (CHUA).
Methods: Between November 2001 and December 2005, 126 patients with SUI have completed a questionnaire in our centre, before and after undergoing surgery with sling techniques. The questionnaire was the King's Health Questionnaire (KHQ), which is a specific instrument for the measurement of quality of life in patients with urinary incontinence.