Publications by authors named "Carlos Martin Loza"
Background: Nodal staging constitutes an element of great importance in the treatment planning for early breast cancer. The ACOSOG Z0011 trial demonstrated that sentinel lymph node (SLN) biopsy alone results in rates of local control, disease-free survival, and overall survival equivalent to those seen after axillary lymph node dissection. The purpose of this study was to determine the rate of patients that fulfill the ACOSOG Z0011 inclusion criteria and to define predictive factors for non-SLN positivity.
View Article and Find Full Text PDFArticle Synopsis
- Breast cancer shows significant variation in clinical and molecular traits, making immune response a critical factor in patient outcomes, though immune prognostic markers lack full validation for clinical use.
- A study analyzed immune features in the blood of 85 nonmetastatic breast cancer patients at diagnosis, revealing increased lymphocyte counts in nonrelapsed patients and a high neutrophil-to-lymphocyte ratio linked to better disease-free survival.
- The findings support the idea of immune surveillance and suggest an "immune phenotype" that could aid in prognosis and treatment decisions for early-stage breast cancer patients.
Purpose: Several studies have shown that estrogen receptor (ER) and progesterone receptor (PR) expression and human epidermal growth factor receptor 2 (HER2) expression may vary during tumoral progression. We aimed to describe and compare ER, PR, and HER2 expressions in primary breast tumors and synchronic axillary nodal metastases, and evaluate phenotypic correlations between them.
Methods: Patients were identified prospectively through surgical procedures between September 2013 and July 2016.