Publications by authors named "Carlos M de Barros"
This research delves into the consequences of consistent pinprick stimulation on preterm offspring to ascertain its long-term implications for pain sensitivity. The primary objective of this protocol was to investigate the impact of neonatal pinprick stimuli on the pain threshold in the later stages of life using a preterm rat model. By establishing this model, we aim to advance the research on understanding and managing early postnatal pain associated with prematurity.
View Article and Find Full Text PDFEffectiveness of epidural morphine for the treatment of cancer pain in patients with gastrointestinal neoplasm-a systematic review.
Naunyn Schmiedebergs Arch Pharmacol
June 2024
One-third of cancer pain patients do not experience adequate pain relief using analgesic ladder by the World Health Organization. Interventional procedures, such as epidural morphine, have been considered. This study aimed to review the literature comparing the effects of epidural administration of morphine with the oral route.
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- - This study investigates the cost-effectiveness of using epidural morphine and ropivacaine for managing severe cancer pain in gastrointestinal cancer patients compared to traditional oral treatments.
- - It involved 24 patients divided into two groups: one receiving oral medication and the other undergoing a surgical procedure for epidural pain management, with pain levels monitored using a Visual Analogue Scale.
- - The economic analysis focused on treatment costs from 2021, examining expenses associated with different treatment phases, and included sensitivity analyses to evaluate the impact of pain relief effectiveness on cost outcomes.
Article Synopsis
- * The study assessed the effectiveness of pregabalin in reducing postoperative pain in female patients undergoing abdominal hysterectomy, comparing it to a placebo.
- * Results showed that patients who took pregabalin experienced significantly lower pain levels and required less opioid medication than those on the placebo, although they reported more dizziness as a side effect.
Background: Chloroquine (CQ) and hydroxychloroquine (HCQ) are old drugs used against malaria, rheumatism, inflammation in the joints, lupus, among others. These drugs showed positive results in preliminary scientific research for treatment of the severe acute respiratory syndrome coronavirus (SARS-CoV-2). Since the studies with CQ and HCQ are initial with small patient populations, it is not yet known whether there are adverse effects from the use of CQ and HCQ for patients infected with the coronavirus.
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