Wriggly woes: Helminths stirring up T cell trouble.

Understanding determinants of immune response variation is central to developing treatment options. Even et al. show that naive CD4 T cell transcriptional heterogeneity is altered by helminth infection leading to impaired immune responses independent of commensals.

Progressive alterations in amino acid and lipid metabolism correlate with peripheral neuropathy in mice.

Mitochondria are central to metabolic homeostasis, and progressive mitochondrial defects have diverse metabolic consequences that could drive distinct pathophysiological states. Here, we comprehensively characterized metabolic alterations in mice. Plasma alanine increased markedly with time, with other organic acids accumulating to a lesser extent.