Publications by authors named "Carlos Lopez-Candiani"
Preterm newborns are extremely vulnerable to morbidities, complications, and death. Preterm birth is a global public health problem due to its socioeconomic burden. Nurturing preterm newborns is a critical medical issue because they have limited nutrient stores and it is difficult to establish enteral feeding, which leads to inadequate growth frequently associated with poor neurodevelopmental outcomes.
View Article and Find Full Text PDFGenetic spectrum and clinical early natural history of glucose-6-phosphate dehydrogenase deficiency in Mexican children detected through newborn screening.
Orphanet J Rare Dis
February 2021
Article Synopsis
- Glucose-6-phosphate dehydrogenase deficiency (G6PDd) screening for newborns is controversial due to varying prevalence rates and limited understanding of its natural progression.
- A study involving 81 newborns found that most had non-hospitalized neonatal jaundice (NNJ), while genotyping revealed a diversity of G6PDd genotypes, with G6PD A being the most common.
- The research highlighted significant variability in enzymatic activity levels among affected infants, indicating a complex relationship between genotype and clinical symptoms, with no notable difference in UGT1A1*28 homozygosity between those with and without NNJ.*
is the etiological agent of toxoplasmosis. Mother-to-child transmission of this parasite can occur during pregnancy. Newborns with congenital toxoplasmosis may develop central nervous system impairment, with severity ranging from subclinical manifestations to death.
View Article and Find Full Text PDFBackground: Screening for infectious diseases in newborns using immunoglobulin (Ig)A-, IgM-, and IgE-specific antibodies is expensive and impractical. To determine if total levels of these Igs can be used for screening purposes, thus simplifying the process, their basic levels in the 1(st) month of extrauterine life need to be determined. Additionally, the ability to simplify screening by using saliva also needs to be determined.
View Article and Find Full Text PDFToxoplasma gondii congenital transmission depends partially on parasite load and genotype. Both factors were examined in 4 mother/newborn pairs with perinatal infection acquired in central Mexico. Type I and type I-related strains were identified.
View Article and Find Full Text PDFObjective: To compare the epidemiological, clinical and microbiological profiles between patients with neonatal sepsis who lived or died.
Material And Methods: The medical records of patients with neonatal sepsis were retrospectively reviewed at Instituto Nacional de Pediatría (National Pediatric Institute) of Secretaría de Salud (Ministry of Health) in Mexico City, between 1992 and 2000. Neonatal sepsis cases were classified as surviving or not after 90 days of postnatal follow-up.