Targeting Neutrophil Extracellular Trap Formation: Exploring Promising Pharmacological Strategies for the Treatment of Preeclampsia.

Neutrophils, which constitute the most abundant leukocytes in human blood, emerge as crucial players in the induction of endothelial cell death and the modulation of endothelial cell responses under both physiological and pathological conditions. The hallmark of preeclampsia is endothelial dysfunction induced by systemic inflammation, in which neutrophils, particularly through the formation of neutrophil extracellular traps (NETs), play a pivotal role in the development and perpetuation of endothelial dysfunction and the hypertensive state. Considering the potential of numerous pharmaceutical agents to attenuate NET formation (NETosis) in preeclampsia, a comprehensive assessment of the extensively studied candidates becomes imperative.

Longitudinal In-Bed Pressure Signals Decomposition and Gradients Analysis for Pressure Injury Monitoring.

Pressure injury (PI) is a major problem for patients that are bound to a wheelchair or bed, such as seniors or people with spinal cord injuries. This condition can be life threatening in its later stages. It can be very costly to the healthcare system as well.

ECG Signal Denoising and Features Extraction Using Unbiased FIR Smoothing.

Methods of the electrocardiography (ECG) signal features extraction are required to detect heart abnormalities and different kinds of diseases. However, different artefacts and measurement noise often hinder providing accurate features extraction. One of the standard techniques developed for ECG signals employs linear prediction.