Publications by authors named "Carlos Lampreave"
Article Synopsis
- The IS6110 insertion sequence has been a crucial genetic marker for tracking tuberculosis (TB) in the Mycobacterium tuberculosis Complex (MTBC) for over 25 years, but its biological impact on MTBC's adaptation to humans is not fully understood.
- A study of 2,236 clinical isolates indicated a higher presence of IS6110 in modern strains of MTBC, with findings suggesting a link between the amount of IS6110 and its expression in the bacteria's chromosomes.
- Further investigation revealed that the transposition of IS6110 is regulated by specific molecular mechanisms and occurs more frequently during TB infection in mice and prolonged lab culture, indicating a dynamic adaptation to host conditions.
