Publications by authors named "Carlos L Macedo-Filho"
Sacroiliac joint involvement is one of the earliest manifestations of psoriatic arthritis (PsA). Magnetic resonance imaging (MRI) is a useful tool in the early diagnosis of axial disease due to its sensitivity for detecting acute and chronic changes associated with sacroiliitis. In this study, we evaluated the prevalence of sacroiliitis, acute and structural image changes on MRI in PsA patients and identified predictive clinical, laboratory and disease activity factors.
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- The study examined the effects of Plectranthus barbatus essential oil (PBEO) on guinea-pig ileum contractility, showing significant reductions in contraction responses compared to its main components like alpha-pinene.
- PBEO achieved a maximum inhibition of phasic contractions triggered by acetylcholine and was highly effective against contractions induced by histamine and barium chloride.
- The results indicate PBEO’s potential as an intestinal relaxant and antispasmodic agent, acting through mechanisms that do not solely rely on blocking neurotransmitter receptors but likely involve calcium dynamics within the cells.