Publications by authors named "Carlos J Torres-Sanchez"
Route-dependent effect of nutritional support on liver glucose uptake.
Am J Physiol Regul Integr Comp Physiol
November 2005
The liver is a major site of glucose disposal during chronic (5 day) total parenteral (TPN) and enteral (TEN) nutrition. Net hepatic glucose uptake (NHGU) is dependent on the route of delivery when only glucose is delivered acutely; however, the hepatic response to chronic TPN and TEN is very similar. We aimed to determine whether the route of nutrient delivery altered the acute (first 8 h) response of the liver and whether chronic enteral delivery of glucose alone could augment the adaptive response to TPN.
View Article and Find Full Text PDFTime course of the hepatic adaptation to TPN: interaction with glycogen depletion.
Am J Physiol Endocrinol Metab
January 2005
Article Synopsis
- The liver significantly adapts to chronic TPN (total parenteral nutrition) by utilizing around 45% of exogenous glucose while mostly releasing glucose as lactate instead of storing it as glycogen.
- This study monitored the adaptation process in dogs receiving TPN after fasting periods of either 18 or 42 hours, showing that both groups exhibited progressive increases in glucose uptake and lactate release over time.
- The key findings indicate that major hepatic adaptations occur within the first 24 hours of TPN initiation, and prior glycogen depletion does not enhance this adaptation rate.