Publications by authors named "Carlos J Herrero"
Article Synopsis
- Catestatin, a fragment of chromogranin A, is the first known natural inhibitor of catecholamine release by blocking activation of neuronal nicotinic acetylcholine receptors (nAChRs) across various species and cell types.
- This study investigates catestatin's effects on nAChR subunit combinations and its role in regulating intracellular calcium levels and catecholamine release in adrenal chromaffin cells.
- Results indicate that catestatin effectively blocks all nAChR subtypes tested, reducing intracellular calcium and catecholamine release without impacting the final stages of exocytosis, suggesting a complex regulatory role in neuroendocrine secretion based on the intensity of stimulation.
