Geraniol and linalool anticandidal activity, genotoxic potential and embryotoxic effect on zebrafish.

Aim: Geraniol and linalool are major constituents of the essential oils of medicinal plants.

Materials & Methods: Antifungal activity of geraniol and linalool were evaluated against five Candida species. The genotoxicity of these compounds was evaluated by the cytokinesis-block micronucleus test, and the embryotoxic assays use zebrafish model.

Kaurenoic acid and its sodium salt derivative: antibacterial activity against Porphyromonas gingivalis and their mechanism of action.

Aim: To evaluate the antibacterial activity of 12 kaurane-type diterpenes against a panel of bacteria that cause endodontic infection.

Methods & Materials: We conducted tests against bacteria in the planktonic or in the sessile mode, cytotoxic assays for the most promising compounds against human normal lung fibroblast cells, and Porphyromonas gingivalis (ATCC 33277) proteomic analysis.

Results & Conclusion: Kaurenoic acid and its salt exhibited satisfactory antibacterial action against the evaluated bacteria.