Publications by authors named "Carlos Hagen"
Introduction: Medical departments have evolved from a position of support to one of strategic leadership. The number of tasks and the complexity of interactions in which they are involved is increasing. However, the spectrum of their activity in the sector differs significantly from one company to another.
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- The 21-gene Oncotype DX Breast Recurrence Score assay is used to predict chemotherapy benefits and guide treatment decisions in early breast cancer (EBC) patients with specific high-risk features.
- The KARMA Dx study involved patients who were initially recommended chemotherapy, and results showed that after testing, 67% of them had their treatment adjusted from chemotherapy to endocrine therapy alone.
- The findings suggest that the 21-gene test significantly reduces the need for chemotherapy in high-risk EBC patients, while also increasing physician confidence in treatment recommendations.
Aim: We aimed to identify SNPs associated with cabazitaxel toxicity and response within a Phase II clinical trial using this compound in advanced transitional cell carcinoma after progression to a platinum-based regimen.
Patients & Methods: Eleven SNPs in CYP3A4, CYP3A5, CYP2C8, ABCB1 and TUBB1 were genotyped in 45 patients.
Results: CYP3A5 rs776746 A allele was associated with protection against gastrointestinal toxicity (odds ratio: 0.
Endocannabinoids are lipid mediators with protective effects in many diseases of the nervous system. We have studied the modulation of the endocannabinoid system after a spinal cord contusion in rats. In early stages, lesion induced increases of anandamide and palmitoylethanolamide (PEA) levels, an upregulation of the synthesizing enzyme NAPE-phospholipase D and a downregulation of the degradative enzyme FAAH.
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