Publications by authors named "Carlos Gracia-Fernandez"

The TTS package has been developed in R software to predict the mechanical properties of viscoelastic materials, at short and long observation times/frequencies by applying the Time Temperature Superposition (TTS) principle. TTS is a physical principle used in material science to estimate mechanical properties beyond the experimental range of observed times/frequencies by shifting data curves obtained at other temperatures relative to a reference temperature in the dataset. It is a methodology related to accelerated life-tests and reliability, whereas the TTS library is one of the first open source computational tool to apply the TTS principle.

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Article Synopsis
  • - Gelatin is a widely used biopolymer in medicine because it's safe and doesn't trigger inflammation, and it can form Ionogels with ionic liquids (ILs) as cosolvents for better drug delivery.
  • - The study focuses on using a specific IL, 1-ethyl-3-methylpyridinium perfluorobutanesulfonate (FIL), with fish gelatin to enhance the solubility of drugs like Doxorubicin while maintaining the mechanical and nanostructural properties of the material.
  • - Controlled release mechanisms of Doxorubicin and Mithramycin from different Ionogel formulations were compared to traditional gelatin hydrogels, highlighting the importance of structural design for
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A series of bionanocomposites composed of shark gelatin hydrogels and PLA nanoparticles featuring different nanostructures were designed to generate multifunctional drug delivery systems with tailored release rates required for personalized treatment approaches. The global conception of the systems was considered from the desired customization of the drug release while featuring the viscoelastic properties needed for their ease of storage and posterior local administration as well as their biocompatibility and cell growth capability for the successful administration at the biomolecular level. The hydrogel matrix offers the support to develop a direct thermal method to convert the typical kinetic trapped nanostructures afforded by the formulation method whilst avoiding the detrimental nanoparticle agglomeration that diminishes their therapeutic effect.

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Article Synopsis
  • Yellowfin tuna skin, rich in collagen, presents a valuable opportunity for innovation in the fishery industry by being transformed into gelatin and hydrogels ideal for drug delivery.
  • The study developed novel tuna gelatin hydrogels to deliver antitumoral drugs Doxorubicin and Crocin locally after surgery, showing favorable mechanical properties and drug release profiles.
  • Various analytical techniques confirmed the structural composition and effectiveness of the gelatin hydrogels, revealing their ability to improve sustained release of the drugs, highlighting the significance of their structure in therapeutic applications.
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Purpose: This work shows an effective methodology to evaluate the dynamic viscoelastic behavior of silicones for application in podiatry. The aim is to characterize, compare their viscoelastic properties according to the dynamic stresses they can be presumably subjected when used in podiatry orthotic applications. These results provide a deeper insight which extends the previous creep-recovery results to the world of dynamic stresses developed in physical activity.

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Homogeneous stable suspensions obtained by dispersing dry TiO2 nanoparticles in pure ethylene glycol were prepared and studied. Two types of nanocrystalline structure were analyzed, namely anatase and rutile phases, which have been characterized by scanning electron microscopy. The rheological behavior was determined for both nanofluids at nanoparticle mass concentrations up to 25%, including flow curves and frequency-dependent storage and loss moduli, using a cone-plate rotational rheometer.

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