Natural History of Conversion of Leber's Hereditary Optic Neuropathy: A Prospective Case Series.

Purpose: To illustrate the natural history of Leber's hereditary optic neuropathy (LHON).

Design: Prospective observational case series.

Participants: The Soave-Brazil pedigree of m.

The pupil light reflex in Leber's hereditary optic neuropathy: evidence for preservation of melanopsin-expressing retinal ganglion cells.

Purpose: To investigate the pupillary light reflex (PLR) of patients with severe loss of vision due to Leber's Hereditary Optic Neuropathy (LHON) in the context of a proposed preservation of melanopsin-expressing retinal ganglion cells (mRGCs).

Methods: Ten LHON patients (7 males; 51.6 ± 14.

Effect of EPI-743 on the clinical course of the mitochondrial disease Leber hereditary optic neuropathy.

Objective: To evaluate the safety and efficacy of a new therapeutic agent, EPI-743, in Leber hereditary optic neuropathy (LHON) using standard clinical, anatomic, and functional visual outcome measures.

Design: Open-label clinical trial.

Setting: University medical center.

Nonarteritic anterior ischemic optic neuropathy after uneventful phacoemulsification: case report.

To report a case of nonarteritic anterior ischemic optic neuropathy (NAION) after uneventful cataract extraction and intraocular lens implantation. Prospective, observational case report and literature review. We report the case history of a 74-year-old woman who underwent phacoemulsification and developed sudden loss of vision on the 13th postoperative day.

Giant cavernous malformation of the occipital lobe.

A 15-year-old boy who developed severe headaches and an incomplete homonymous hemianopia was found to have a large, well-circumscribed, multilobulated intracranial mass in the contralateral occipital lobe. The initial impression was that of a low-grade glioma or a vascular malformation. When the lesion increased in size and complexity, concern arose about the possibility of a malignant glioma.

Visual outcome in surgically treated suprasellar meningiomas.

OBJECTIVE To determine long-term (>10 years) visual outcome in patients with suprasellar meningiomas. METHODS Retrospective case series.RESULTS Among 18 patients who underwent surgery for suprasellar meningioma (1 patient died postoperatively), 1 experienced initial improvement in vision in both eyes, 8 experienced improvement in vision in one eye and maintained stable vision in the other eye, 2 experienced improvement in vision in one eye and worsening of vision in the other, 3 experienced worsening of vision in one eye and stable vision in one eye, and 4 maintained stable visual acuity in both eyes.