Publications by authors named "Carlos Fernandez Llatas"

Article Synopsis
  • Process mining techniques can improve the analysis of longitudinal data in clinical epidemiology, but their use has been limited.
  • This study proposes an eight-step methodology that combines cohort studies with process mining to uncover disease progression patterns.
  • By applying this methodology, researchers found that proton pump inhibitors (PPIs) led to higher risks of kidney decline and all-cause mortality compared to H2 blockers, and they developed a prediction tool for assessing individual risk.
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Previous studies have suggested an association between Proton Pump Inhibitors (PPIs) and the progression of chronic kidney disease (CKD). This study aims to assess the association between PPI use and CKD progression by analysing estimated glomerular filtration rate (eGFR) trajectories using a process mining approach. We conducted a retrospective cohort study from 1 January 2006 to 31 December 2011, utilising data from the Stockholm Creatinine Measurements (SCREAM).

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Background: Despite substantial progress in AI research for healthcare, translating research achievements to AI systems in clinical settings is challenging and, in many cases, unsatisfactory. As a result, many AI investments have stalled at the prototype level, never reaching clinical settings.

Objective: To improve the chances of future AI implementation projects succeeding, we analyzed the experiences of clinical AI system implementers to better understand the challenges and success factors in their implementations.

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The widespread use of information technology in healthcare leads to extensive data collection, which can be utilised to enhance patient care and manage chronic illnesses. Our objective is to summarise previous studies that have used data mining or process mining methods in the context of chronic diseases in order to identify research trends and future opportunities. The review covers articles that pertain to the application of data mining or process mining methods on chronic diseases that were published between 2000 and 2022.

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The World Health Organization has estimated that air pollution will be one of the most significant challenges related to the environment in the following years, and air quality monitoring and climate change mitigation actions have been promoted due to the Paris Agreement because of their impact on mortality risk. Thus, generating a methodology that supports experts in making decisions based on exposure data, identifying exposure-related activities, and proposing mitigation scenarios is essential. In this context, the emergence of Interactive Process Mining-a discipline that has progressed in the last years in healthcare-could help to develop a methodology based on human knowledge.

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Participatory design (PD) is increasingly used to support design and development of digital health solutions. The involves representatives of future user groups and experts to collect their needs and preferences and ensure easy to use and useful solutions. However, reflections and experiences with PD in designing digital health solutions are rarely reported.

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Objectives: In ST-segment elevation myocardial infarction (STEMI), time delay between symptom onset and treatment is critical to improve outcome. The expected transport delay between patient location and percutaneous coronary intervention (PCI) centre is paramount for choosing the adequate reperfusion therapy. The "Centro" region of Portugal has heterogeneity in PCI assess due to geographical reasons.

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Introduction: Cancer is a primary public concern in the European continent. Due to the large case numbers and survival rates, a significant population is living with cancer needs. Consequently, health professionals must deal with complex treatment decision-making processes.

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Article Synopsis
  • * The Process-Oriented Data Science community emphasizes the importance of collaboration between medical experts and data scientists to create tools that enhance understanding and improve healthcare processes.
  • * Techniques like Process Mining are suggested as effective methods for developing user-friendly AI solutions that allow medical professionals to actively participate in uncovering real-world evidence, improving the overall quality of care.
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Article Synopsis
  • - Process mining techniques analyze business processes using execution data, particularly in healthcare to evaluate diagnostic, treatment, and organizational workflows.
  • - Despite the vast data generated in hospitals, rigorous adoption of process mining is limited to specific case studies, pointing to a lack of systematic integration in healthcare settings.
  • - The Process-Oriented Data Science in Healthcare Alliance aims to enhance research and application of process mining in healthcare by addressing unique challenges, such as process variability and patient focus.
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Aging population increase demands for solutions to help the solo-resident elderly live independently. Unobtrusive data collection in a smart home environment can monitor and assess elderly residents' health state based on changes in their mobility patterns. In this paper, a smart home system testbed setup for a solo-resident house is discussed and evaluated.

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Article Synopsis
  • * Current risk models typically use static health data, limiting personalized care; this research aims to develop dynamic models reflecting ongoing patient behaviors through Process Mining techniques.
  • * The study identified three dynamic models for hypertension, obesity, and diabetes, advocating for a shift from generic treatments to personalized medicine based on individual patient behaviors and sensor data.
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In the age of Evidence-Based Medicine, Clinical Guidelines (CGs) are recognized to be an indispensable tool to support physicians in their daily clinical practice. Medical Informatics is expected to play a relevant role in facilitating diffusion and adoption of CGs. However, the past pioneering approaches, often fragmented in many disciplines, did not lead to solutions that are actually exploited in hospitals.

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Article Synopsis
  • * Process mining, which analyzes execution data from health information systems, offers insights for evidence-based improvement but has limited implementation in real-world healthcare settings outside research contexts.
  • * An international seminar aimed to boost the use of process mining in healthcare, resulting in recommendations for researchers and healthcare organizations to enhance its usability and continuous application.
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This article proposes the analysis of the admissions to hospital-at-home service within the framework of process mining. In addition to conventional modeling in standard languages, relying on interviews and continuous improvement, we propose the adoption of an automatic process discovery technique based on data collected by the hospital information system. We focus on the patient admission process, in which staff discriminate cases of interest for the service.

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Patients with type 2 diabetes have a higher chance of developing cardiovascular diseases and an increased odds of mortality. Reliability of randomized clinical trials is continuously judged due to selection, attrition and reporting bias. Moreover, cardiovascular risk is frequently assessed in cross-sectional studies instead of observing the evolution of risk in longitudinal cohorts.

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The application of Value-based Healthcare requires not only the identification of key processes in the clinical domain but also an adequate analysis of the value chain delivered to the patient. Data Science and Big Data approaches are technologies that enable the creation of accurate systems that model reality. However, classical Data Mining techniques are presented by professionals as black boxes.

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The study presents some results of customer paths' analysis in a shopping mall. Bluetooth-based technology is used to collect data. The event log containing spatiotemporal information is analyzed with process mining.

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The widespread adoption of real-time location systems is boosting the development of software applications to track persons and assets in hospitals. Among the vast amount of applications, real-time location systems in operating rooms have the advantage of grounding advanced data analysis techniques to improve surgical processes, such as process mining. However, such applications still find entrance barriers in the clinical context.

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Background: Expressing anthropometric parameters (height, weight, BMI) as z-score is a key principle in the clinical assessment of children and adolescents. The Centre for Disease Control and Prevention (CDC) growth charts and the CDC-LMS method for z-score calculation are widely used to assess growth and nutritional status, though they can be imprecise in some percentiles.

Objective: To improve the accuracy of z-score calculation by revising the statistical method using the original data used to develop current z-score calculators.

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Background: Research in type 1 diabetes management has increased exponentially since the irruption of mobile health apps for its remote and self-management. Despite this fact, the features affect in the disease management and patient empowerment are adopted by app makers and provided to the general population remain unexplored.

Objective: To study the gap between literature and available apps for type 1 diabetes self-management and patient empowerment and to discover the features that an ideal app should provide to people with diabetes.

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Detection of abnormal cardiac events during clinical examination is a matter of chances, as such events may not happen at that precise moment. We therefore propose the implementation and evaluation of a mobile based system that allows a real-time detection of cardiovascular problems related to heart-rate variability. Our approach is to integrate an Internet of Things eHealth kit based on Arduino and validated algorithms for heart rate variability to build a low-cost, reliable and scalable solution.

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