Publications by authors named "Carlos Enrique Muskus-Lopez"

Nonviral transfection has important implications on gene therapy because of its safety. In particular, polyfection and nucleofection are two widely used systems for nonviral gene delivery. Their potential depends on the transfection efficiency achieved, which is influenced in turn by the type of cells transfected and by the plasmid that carries the gene of interest.

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Article Synopsis
  • Polymorphic variants in the FCGR3A gene are linked to reduced function in natural killer (NK) cells, affecting how they kill infected or cancerous cells in humans.
  • A specialized genotyping strategy was developed for identifying these variants in a study involving 115 Colombian participants, successfully differentiating FCGR3A from a similar gene (FCGR3B).
  • Findings revealed specific allele frequencies and suggested a relationship between the variants and NK cell activity, including an effect on antibody reactivity but not on NK cell-mediated cytotoxicity.
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Biofilm is an extremely complex microbial community arranged in a matrix of polysaccharides and attached to a substrate. Its development is crucial in the pathophysiology of oral infections like dental caries, as well as in periodontal, pulp, and periapical diseases. Streptococcus mutans is one of the most effective microorganisms in lactic acid production of the dental biofilm.

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Familial Hemophagocytic Lymphohistiocytosis type 2 (FHL2) results from mutations in PRF1. We described two unrelated individuals who presented with FHL, in whom severely impaired NK cytotoxicity and decrease perforin expression was observed. DNA sequencing of PRF1 demonstrated that both were not only heterozygous for the p.

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