Zinc treatment ameliorates diarrhea and intestinal inflammation in undernourished rats.

Background: WHO guidelines recommend zinc supplementation as a key adjunct therapy for childhood diarrhea in developing countries, however zinc's anti-diarrheal effects remain only partially understood. Recently, it has been recognized that low-grade inflammation may influence stunting. In this study, we examined whether oral zinc supplementation could improve weight, intestinal inflammation, and diarrhea in undernourished weanling rats.

Zinc and glutamine improve brain development in suckling mice subjected to early postnatal malnutrition.

Objective: The effect of zinc and glutamine on brain development was investigated during the lactation period in Swiss mice.

Methods: Malnutrition was induced by clustering the litter size from 6-7 pups/dam (nourished control) to 12-14 pups/dam (undernourished control) following birth. Undernourished groups received daily supplementation with glutamine by subcutaneous injections starting at day 2 and continuing until day 14.