Pharmacoresistant seizures and IDH mutation in low-grade gliomas.

Background: Many low-grade gliomas (LGG) harbor isocitrate dehydrogenase (IDH) mutations. Although mutation is known to be epileptogenic, the rate of refractory seizures in LGG with mutation vs wild-type had not been previously compared. We therefore compared seizure pharmacoresistance in -mutated and wild-type LGGs.

Central Nervous System Lymphoma: Approach to Diagnosis and Treatment.

Central nervous system lymphoma (CNSL) is a rare form of extranodal non-Hodgkin lymphoma. Central nervous system lymphoma can be primary (isolated to the central nervous space) or secondary in the setting of systemic disease. Treatment of CNSL has improved since the introduction of high-dose methotrexate and aggressive consolidation regimens.