Publications by authors named "Carlos Eduardo Baston Silva"
Molecular profile of driver genes in lung adenocarcinomas of Brazilian patients who have never smoked: implications for targeted therapies.
Rodrigo de Oliveira Cavagna Flávia Escremim de Paula Gustavo Noriz Berardinelli Murilo Bonatelli Iara Santana Eduardo Caetano Albino da Silva Flávio Augusto Ferreira da Silva Carlos Eduardo Baston Silva
Oncologist
October 2024
Article Synopsis
- LCINS accounts for 20% of lung cancer cases, with the study focusing on the molecular profile of driver genes in Brazilian patients who never smoked.
- The investigation involved studying mutational and gene fusion status in 119 lung adenocarcinomas using advanced sequencing techniques, alongside genetic ancestry analysis.
- Results showed high mutation rates in genes like EGFR and TP53, with significant findings on ancestry influencing mutation patterns, and highlighted that a large percentage of patients have potential targets for effective treatment.
Detection of NTRK fusions by RNA-based nCounter is a feasible diagnostic methodology in a real-world scenario for non-small cell lung cancer assessment.
Rodrigo de Oliveira Cavagna Edilene Santos de Andrade Monise Tadin Reis Flávia Escremim de Paula Gustavo Noriz Berardinelli Flávio Augusto Ferreira da Silva Carlos Eduardo Baston Silva
Sci Rep
December 2023
Article Synopsis
- * A study in Brazil found that out of 147 NSCLC patients, 8.2% tested positive for NTRK fusions via immunohistochemistry, with two cases confirmed using RNA-based methods.
- * The study revealed that NTRK fusions are relatively rare in this population and highlighted the effectiveness of RNA-based nCounter for identifying NTRK fusions in small biopsy samples, with a low concordance rate between different testing methods.