Association between Polymorphisms in Inflammatory Response-Related Genes and the Susceptibility, Progression and Prognosis of the Diffuse Histological Subtype of Gastric Cancer.

The chronic inflammatory microenvironment and immune cell dysfunction have been described as critical components for gastric tumor initiation and progression. The diffuse subtype is related to poor clinical outcomes, pronounced inflammation, and the worst prognosis. We investigated the association of polymorphisms in inflammatory response-related genes (, , , , , , , , , , and ) with gastric cancer susceptibility, progression and prognosis in a Brazilian sample, focusing on the diffuse subtype.

Laparoscopic D2 Gastrectomy for Gastric Cancer: Mid-Term Results and Current Evidence.

Introduction: Although the first laparoscopic gastrectomy was performed in 1991, there was a long delay until it was incorporated into the regular practice of western surgeons. In Brazil, there are only few case series reported and data on its safety and efficacy along with mid- and long-term results are desired.

Objective: Present the mid-term results of laparoscopic gastrectomy with curative intent in the treatment of gastric adenocarcinoma and review the current evidence on the therapy of this neoplasia with the laparoscopic access.

Validation of classic and expanded criteria for endoscopic submucosal dissection of early gastric cancer: 7 years of experience in a Western tertiary cancer center.

Objective: Our aim was to evaluate the Japan Gastroenterological Endoscopy Society criteria for endoscopic submucosal resection of early gastric cancer (EGC) based on the experience in a Brazilian cancer center.

Methods: We included all patients who underwent endoscopic submucosal resection for gastric lesions between February 2009 and October 2016. Demographic data and information regarding the endoscopic resection, pathological report and follow-up were obtained.

Risk assessment of lymph node metastases in early gastric adenocarcinoma fulfilling expanded endoscopic resection criteria.

Background And Aims: Early gastric cancer (EGC) is known to present a low rate of lymph node metastases (LNMs). Gastrectomy with D2 lymphadenectomy is usually curative for EGC. Endoscopic submucosal dissection (ESD) is a well-accepted treatment modality for lesions that meet the classic criteria: those mucosal differentiated adenocarcinoma measuring 20 mm or less, without ulceration.

Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma.

The aim of the present study was to determine the clinical significance of p53 and p21 p21, p27 and p16 expression in cases of early gastric cancer. A total of 81 patients who had undergone gastrectomy with D2 lymphadenectomy between 1971 and 2004 were retrospectively investigated. The immunohistochemical expression of p21, p53, p21, p27 and p16 in the tissues was evaluated.

GASTRIC NEUROENDOCRINE TUMOR: REVIEW AND UPDATE.

Introduction: The frequency of gastric neuroendocrine tumors is increasing. Reasons are the popularization of endoscopy and its technical refinements. Despite this, they are still poorly understood and have complex management.

Minimally invasive surgery for gastric cancer in Brazil: current status and perspectives-a report from the Brazilian Laparoscopic Oncologic Gastrectomy Group (BLOGG).

The minimally invasive surgery for gastric cancer in Brazil has begun about two years after the first laparoscopic gastrectomy (LG) performed by Kitano in Japan, in 1991. Although the report of first surgeries shows the year of 1993, there was no dissemination of the technique until the years 2010. At that time with the improvement of optical devices, laparoscopic instruments and with the publications coming from Asia, several Brazilian surgeons felt encouraged to go to Korea and Japan to learn the standardization of the LG.

Favorable minimal invasive surgery in the treatment of superior mesenteric artery syndrome: Case report.

Introduction: The Superior Mesenteric Artery Syndrome (SMAS) is a rare form of intestinal obstruction. The diagnosis is based on findings from imaging studies, including vascular compression of the duodenum by the SMA and can be associated with duodenal dilatation.

Presentation Of Case: We report a case of a patient with SMAS and recurrent episodes of intestinal obstruction, which was successfully treated by laparoscopic duodenojejunostomy.

MINIMALLY INVASIVE SURGERY FOR GASTRIC CANCER: TIME TO CHANGE THE PARADIGM.

Introduction: Minimally invasive surgery widely used to treat benign disorders of the digestive system, has become the focus of intense study in recent years in the field of surgical oncology. Since then, the experience with this kind of approach has grown, aiming to provide the same oncological outcomes and survival to conventional surgery. Regarding gastric cancer, surgery is still considered the only curative treatment, considering the extent of resection and lymphadenectomy performed.

Robotic digestive tract reconstruction after total gastrectomy for gastric cancer: a simple way to do it.

Background: Intracorporeal digestive tract reconstruction after minimally invasive total gastrectomy may be challenging, even when using the da Vinci® Surgical System. This may be due to intrinsic difficulties during oesophago-jejunal anastomosis (EJA). The aim of this study was to describe a simple way to perform digestive tract reconstruction after robotic total gastrectomy (RTG) for gastric cancer and the results of its application in a small series of cases.

Simplified technique for reconstruction of the digestive tract after total and subtotal gastrectomy for gastric cancer.

Background: Laparoscopic surgery has been increasingly applied to gastric cancer surgery. Gastrointestinal tract reconstruction totally done by laparoscopy also has been a challenge for those who developed this procedure.

Aim: To describe simplified reconstruction after total or subtotal gastrectomy for gastric cancer by laparoscopy and the results of its application in a series of cases.

Hepatectomy: a critical analysis on expansion of the indications.

Background: Hepatic resection has evolved to become safer, thereby making it possible to expand the indications. Aim : To assess the results from a group of patients presenting these expanded indications.

Method: Were prospectively studied all the hepatectomy procedures performed for hepatic tumor resection.

The written informed consent form (WICF): factors that interfere with acceptance.

Background: The written informed consent form (WICF) provides information that must be written in simple, easily understood language, highlighting voluntary participation safeguards, risks, possible benefits, and procedures. Currently, the possibility that research subjects do not fully understand the text of the WICF or their rights as participants, despite having signed the WICF and agreed to participate in the study, has been a point of discussion.

Aim: To evaluate the readability of the WICFs, as well as to correlate research subject acceptance of the WICF with demographic status, social factors, risk-benefit relationship, and education level.

Brazilian consensus in gastric cancer: guidelines for gastric cancer in Brazil.

Background: In Brazil, gastric cancer is the fourth most common malignancy among men and sixth among women. The cause is multivariate and the risks are well known. It has prognosis and treatment defined by the location and staging of the tumor and number of lymph nodes resected and involved.

Thromboembolism prevention in surgery of digestive cancer.

Background: The venous thromboembolism is a common complication after surgical treatment in general and, in particular, on the therapeutic management on cancer. Surgery of the digestive tract has been reported to induce this complication. Patients with digestive cancer have substantial increased risk of initial or recurrent thromboembolism.

Results of D2 gastrectomy for gastric cancer: lymph node chain dissection or multiple node resection?

Background: Eastern literature is remarkable for presenting survival rates for surgical treatment of gastric adenocarcinoma superior to those presented in western countries.

Aim: To analyze the long-term result after D2 gastrectomy for gastric cancer.

Methods: Two hundred seventy four underwent gastrectomy with D2 lymph node dissection as exclusive treatment.

Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients.

Gastric cancer is a leading cause of cancer-related mortality, and the presence of lymph node metastasis an important prognostic factor. Downregulation of RKIP has been associated with tumor progression and metastasis in several types of neoplasms, being currently categorized as a metastasis suppressor gene. Our aim was to determine the expression levels of RKIP in gastric tissues and to evaluate its impact in the clinical outcome of gastric carcinoma patients.

The prognostic value of CD147/EMMPRIN is associated with monocarboxylate transporter 1 co-expression in gastric cancer.

The aim of the present work was to assess the role of monocarboxylate transporters (MCTs), namely MCT1 and MCT4 as well as MCT/CD147 co-expression in gastric tissues and evaluate their clinico-pathological significance in gastric carcinoma. For that, we analysed the immunohistochemical expression of MCT1, MCT4 and CD147, in a large series of gastric samples, including non-neoplastic, tumour and metastatic tissues. A significant decrease in MCT4 plasma membrane expression was observed from non-neoplastic to gastric primary malignant tissues and to lymph-node metastasis and both MCT1 and MCT4 correlated with CD147.

Endogastric surgery for gastric diseases--simplifying technical aspects.

Minimally invasive surgery has become the preferred treatment strategy for most gastrointestinal diseases. Owing to specific anatomical reasons and in highly selected patients, gastric diseases offer the opportunity for an endogastric approach. In this setting, 2 different strategies may be used: (1) endogastric mucosectomy for superficial lesions such as highly selected early gastric cancer and (2) stapled wedge resection for intramural lesions such as gastric stromal tumors.

Trends in tumor location in gastric carcinoma over a 28-year period.

Background/aims: Gastric cancer is still a leading cause of cancer death in the world and in Brazil. Historically a majority of gastric tumors were located in the distal third of the stomach. However, several studies have shown a shift in tumor location towards the proximal third.

Rectal procidentia treatment by perineal rectosigmoidectomy combined with levator ani repair.

Background/aims: Perineal rectosigmoidectomy has gained acceptance as a valid alternative to treat rectal procidentia with the advantage of decreased surgical risk, shorter recovery time, and lower complication rates when compared to abdominal approaches, although controversies still exist about its recurrence rates and functional results. This study aimed to evaluate the results of perineal rectosigmoidectomy combined with repair of the levator ani muscles to treat rectal procidentia.

Methodology: Forty-four patients who underwent perineal rectosigmoidectomy with levatorplasty for rectal procidentia between 1985 and 2000 were retrospectively analyzed.