Effective BPA degradation in water: the integration of bimetallic UiO-66 Ce-Zr.

In this work, a bimetallic MOF UiO-66 Ce-Zr to degrade bisphenol A (BPA) in water was synthesised. The material exhibited a remarkable degradation efficiency of 84.3% under UV irradiation for 240 minutes.

APTES functionalization in SBA-15: the effect on SO capture and detection applications.

The development of adsorbents for air pollutant remediation and effective monitoring is of interest. Then, the effect of the APTES functionalization ratio on the impact of the adsorption and detection of SO molecules was evaluated. The higher APTES functionalization material (SBA-15_6.

Synthesis of Pyrrolo[3,4-]pyridin-5-ones via Ugi-Zhu Reaction and In Vitro-In Silico Studies against Breast Carcinoma.

An Ugi-Zhu three-component reaction (UZ-3CR) coupled in a one-pot manner to a cascade process (-acylation/ Diels-Alder cycloaddition/decarboxylation/dehydration) was performed to synthesize a series of pyrrolo[3,4-]pyridin-5-ones in 20% to 92% overall yields using ytterbium triflate as a catalyst, toluene as a solvent, and microwaves as a heat source. The synthesized molecules were evaluated in vitro against breast cancer cell lines MDA-MB-231 and MCF-7, finding that compound , at a concentration of 6.25 μM, exhibited a potential cytotoxic effect.

Synthesis of bis-furyl-pyrrolo[3,4-]pyridin-5-ones Ugi-Zhu reaction and activity assays against human SARS-CoV-2 and studies on its main proteins.

An Ugi-Zhu three-component reaction (UZ-3CR) coupled in one pot manner to a cascade process (-acylation/aza Diels-Alder cycloaddition/decarboxylation/dehydration) was performed to synthesize a series of bis-furyl-pyrrolo[3,4-]pyridin-5-ones in 45 to 82% overall yields using ytterbium triflate as a catalyst, toluene as a solvent, and microwaves as a heat source. The synthesized molecules were evaluated against human SARS-CoV-2 through a time-of-addition approach, finding that compound 1e, at a concentration of 10.0 μM, exhibited a significant reduction at the initial infection stages, thus showing prophylactic potential.