Effect of topical mitomycin-C on total collagen deposits on the submucosa of intact vocal folds in swine.

Objective: To compare the effects of topical mitomycin-C at different concentrations on submucosal collagen deposition on the vocal folds of swine.

Methods: The animals were divided into three groups according to the composition of the topical solution to be applied to the vocal folds: 0.9% saline solution (control group); 4 mg/ml mitomycin-C (group 1) and 8 mg/ml mitomycin-C (group 2).