Platelet-rich plasma, rhOP-1 (rhBMP-7) and frozen rib allograft for the reconstruction of bony mandibular defects in sheep. A pilot experimental study.

A 6 cm bony defect in the mandible of 15 sheep, 8 years old, was reconstructed using variously allograft of frozen rib, rhOP-1 (rh BMP-7), platelet-rich plasma (PRP), and a combination of frozen rib allograft and rhOP-1. The histological, histomorphometric, immunohistochemical and radiographic features of reconstruction were analysed. The animals were euthanised at 2 months postoperatively.

Perioperative high-dose-rate brachytherapy (PHDRB) in previously irradiated head and neck cancer: Initial results of a Phase I/II reirradiation study.

Background: This study was undertaken to determine the feasibility of salvage surgery and perioperative high-dose-rate brachytherapy (PHDRB) at the dose/fractionation schedule proposed in patients with previously irradiated, recurrent head and neck cancer or second primary tumors arising in a previously irradiated field.

Methods And Materials: Twenty-five patients were treated with surgical resection and PHDRB. The PHDRB dose was 4 Gy b.

Repair of large orbito-cutaneous defects by combining two classical flaps.

Introduction: Despite the fact that orbital exenteration is one of the most socially distressing facial operations, it may be necessary, still. The repair of a radically exenterated orbit is a difficult problem for surgeons to resolve.

Material And Patients: In the Department of Oral and Maxillofacial Surgery, Madrid, nine patients underwent orbital exenteration including simultaneous periorbital tissue resection for invasive orbital and/or periorbital tumours between 1990 and 2000.