Publications by authors named "Carlos Celis‐Morales"
Objective: Physical activity (PA) has been generally recognised as beneficial for health. The effect of a change in PA on kidney biomarkers in healthy individuals without kidney disease remains unclear. This manuscript synthesised the evidence of the association of changes in PA with kidney biomarkers in the general population free from kidney disease.
View Article and Find Full Text PDFUnlabelled: There is a divergence in the results of studies that have explored the association between body mass index (BMI) and health outcomes in different contexts.
Aim: This study investigated the association between BMI and all-cause mortality in older Chilean people.
Methods: 1.
Background: Few studies have investigated whether and which anxiety and affective disorders are associated with the risk of venous thromboembolism. We aimed to examine whether anxiety disorder, depression, and bipolar disorder increase the risk of venous thromboembolism, independent of socioeconomic confounders and each other, in a UK general population.
Methods: This is a prospective cohort study using UK Biobank.
Article Synopsis
- Various polymorphisms in the beta-2 adrenergic receptor (ADRB2) gene have links to cardiometabolic issues like hypertension and obesity, but the specific SNP rs12654778 hasn't been studied much, especially in Chile.
- The study aimed to see how the rs12654778 SNP in the ADRB2 gene relates to cardiometabolic risk factors among 404 Chilean adults through analysis of their genotypes (GG, AG, AA).
- Results showed that individuals with the AA genotype had significantly lower levels of low-density lipoprotein (LDL) cholesterol, suggesting a protective effect; this study marks a first for research on this SNP in Chile.
Background: This study aims to explore whether conventional and emerging biomarkers could improve risk discrimination and calibration in secondary prevention of recurrent atherosclerotic cardiovascular disease (ASCVD), based on a model using predictors from SMART2.
Methods: In a cohort of 20,658 UK Biobank participants with medical history of ASCVD, we analysed any improvement in C indices and net reclassification index (NRI) for future ASCVD events, following addition of LP-a, ApoB, cystatin C, HbA1c, GGT, AST, ALT, and ALP, to a model with predictors used in SMART2 for the outcome of recurrent major cardiovascular event. We also examined any improvement in C indices and NRIs replacing creatinine based estimated glomerular filtration rate (eGFR) with cystatin C based estimates.
Associations of Serum Lipid Traits With Fracture and Osteoporosis: A Prospective Cohort Study From the UK Biobank.
J Cachexia Sarcopenia Muscle
December 2024
Background: Previous studies reveal inconsistent associations between serum lipid traits and the risks of fractures and osteoporosis in the general population.
Methods: This prospective cohort study analysed data from 414 302 UK Biobank participants (223 060 women and 191 242 men, aged 37-73 years) with serum lipid measurements: apolipoprotein A (Apo A), apolipoprotein B (Apo B), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and lipoprotein A (Lp(a)). Multivariable Cox proportional hazard models with penalized cubic splines were used to explore potential nonlinear associations of each lipid trait with the risks of fractures and osteoporosis.
Article Synopsis
- The study investigates the prevalence of diabesity (obesity and type 2 diabetes) and prediabesity in Chilean adults, using data from the 2016-2017 National Health Survey with nearly 5,000 participants.
- Findings reveal that 5.7% of participants had diabesity, 3.6% had prediabesity, and 2.5% were categorized as normo-diabetic, with higher rates among women, those with lower education levels, and individuals aged 45-46.
- The overall prevalence of prediabesity and diabesity stands at 9.3%, indicating an urgent need for preventive measures and strategies to address these health issues in the population.
Objectives: To investigate the associations of n-3 fatty acid intake with handgrip strength and muscle mass indices in older adults. A secondary aim was to investigate whether these associations differed by physical activity status.
Research Methods & Procedures: A cross-sectional study included 53,170 participants aged 60 years and over from the UK biobank (25,324 men and 27,846 women).
Background: This study aims to explore the association of childhood maltreatment with obesity and type 2 diabetes (T2D) in adulthood, and whether obesity is a mediator of the latter.
Methods: In a retrospective cohort study using UK Biobank data, participants recalled childhood maltreatment. Linear regression, logistic regression, and Cox proportional hazard models were used to investigate the associations with body mass index (BMI), obesity, and T2D, adjusted for sociodemographic factors.
Article Synopsis
- Researchers studied the visceral adiposity index (VAI), which helps measure belly fat and its link to diseases like cancer.
- They looked at 385,477 people from the UK over about 8 years and found that those with higher VAI levels had a greater risk of developing certain cancers.
- Specifically, higher VAI was connected to increased risks of cancers like uterine, kidney, and breast cancer, indicating that belly fat could play a role in cancer risk.
Effects of video-guided active breaks with curricular content on mental health and classroom climate in chilean schoolchildren aged 6 to 10: study protocol for a multicentre randomized controlled trial.
Front Physiol
September 2024
Article Synopsis
- The prevalence of mental health issues in children is rising globally, with Chile experiencing a notable increase in concerns about school mental health and climate.
- The "Active Classes + School Climate and Mental Health" project is a 12-week intervention program that incorporates video-guided active breaks in classrooms to assess their impact on students' mental health and school environment.
- This study is significant as it is the first in Chile to explore the effects of such active breaks on children's mental health and may provide valuable insights into improving school climate.
Aim: Elevated C-reactive protein (CRP), a marker of inflammation, is common in many chronic conditions. We aimed to examine to what extent elevated CRP in chronic conditions could be explained by concurrent adiposity.
Materials And Methods: This cross-sectional study analysed UK Biobank data on 10 chronic conditions reported at baseline.
Article Synopsis
- Frailty is a common issue among older adults in Chile, but its specific prevalence across different regions had not been previously identified.
- This study analyzed data from over 3,000 participants aged 40 and above to determine frailty levels using a 49-item Frailty Index, categorizing individuals as robust, pre-frail, or frail.
- Results showed that the national prevalence was 47.6% robust, 40.6% pre-frail, and 11.8% frail, with higher frailty rates found in the central regions, particularly among older women and those with lower education levels.
Aim: To evaluate the association of glycated haemoglobin (HbA1c) and serum glucose with intraocular pressure (IOP) in a large UK general population.
Materials And Methods: Participants were selected from the UK Biobank, excluding those with eye conditions that may affect IOP. IOP was measured using an ocular response analyser.
Background: Previous research on the association between physical activity (PA) and kidney function is inconsistent. The association between muscle mass and serum creatinine (SCr) may have implications for interpreting the effect of PA on estimated glomerular filtration rate (eGFR). Few studies have reported changes in physical activity and changes in kidney function.
View Article and Find Full Text PDFIt is elusive why some heavy drinkers progress to severe alcohol-related liver disease (ALD) while others do not. This study aimed to investigate if the association between alcohol consumption and severe ALD is modified by diet. This prospective study included 303,269 UK Biobank participants.
View Article and Find Full Text PDFArticle Synopsis
- The study explored the link between sedentary behavior, the FTO gene, and obesity markers in a Chilean population, focusing on how sedentary time might affect genetic predisposition to obesity.
- Data was gathered from 409 participants, measuring adiposity markers like body weight and BMI, while sedentary behaviors were tracked using accelerometers.
- Findings showed that higher sedentary time is more strongly associated with increased body weight and waist circumference in individuals carrying the risk variant of the FTO gene compared to non-risk carriers.
Article Synopsis
- This study investigates the cardiorespiratory fitness (CRF) levels among Chileans with and without cancer, using data from a large health survey.
- The findings show that individuals diagnosed with cancer had lower CRF compared to those without a diagnosis, particularly among those with colorectal, breast, and uterine cancer.
- The research suggests that CRF tends to decline further as the years since diagnosis increase, highlighting the importance of addressing fitness in cancer care.
Background: Obesity and central obesity are multifactorial conditions with genetic and non-genetic (lifestyle and environmental) contributions. There is incomplete understanding of whether lifestyle modifies the translation from respective genetic risks into phenotypic obesity and central obesity, and to what extent genetic predisposition to obesity and central obesity is mediated via lifestyle factors.
Methods: This is a cross-sectional study of 201,466 (out of approximately 502,000) European participants from UK Biobank and tested for interactions and mediation role of lifestyle factors (diet quality; physical activity levels; total energy intake; sleep duration, and smoking and alcohol intake) between genetic risk for obesity and central obesity.
Article Synopsis
- A Body Shape Index (ABSI) is a new obesity measurement that focuses on body volume and might be better than BMI in predicting health risks related to obesity, especially regarding chronic diseases like type 2 diabetes.
- This study analyzed data from 4,874 Chilean adults to see how ABSI correlates with blood sugar levels, glycosylated hemoglobin (HbA1c), and self-reported type 2 diabetes (T2DM).
- Results showed that higher ABSI scores were strongly linked to increased glycemia, higher HbA1c levels, and greater odds of having T2DM, suggesting ABSI could serve as a useful tool for assessing obesity-related metabolic risks