Feasibility of using real-world free thyroxine data from the US and Europe to enable fast and efficient transfer of reference intervals from one population to another.

Objectives: The direct approach for determining reference intervals (RIs) is not always practical. This study aimed to generate evidence that a real-world data (RWD) approach could be applied to transfer free thyroxine RIs determined in one population to a second population, presenting an alternative to performing multiple RI determinations.

Design And Methods: Two datasets (US, n = 10,000; Europe, n = 10,000) were created from existing RWD.

Sustained hyperkalemia in an asymptomatic primary care patient. When to suspect familial pseudohyperkalemia.

Objectives: Study and management of a case with elevated potassium levels without apparent clinical causes in successive follow-up visits.

Case Presentation: We present the case of a primary care female patient who persistently exhibited elevated levels of potassium (5.3-5.

Participation of the dentate-rubral pathway in the kindling model of epilepsy.

Lesions of the cerebellar dentate nucleus (DN) reduce the after-discharge duration induced by repetitive kindling stimulation and decrease seizures to a lower rank according to Racine's scale. The DN sends cholinergic and glutamatergic fibers to the red nucleus (RN), which is composed of glutamatergic and GABAergic cells. To test the participation of these neurotransmitters in seizures, we compared the levels of glutamate and gamma-aminobutyric acid (GABA) at the RN in a control condition, a kindled stage, and a kindled stage followed by DN lesions.