Publications by authors named "Carlos Augusto Pinheiro de Moraes"
Steroid-resistant idiopathic nephrotic syndrome in children: long-term follow-up and risk factors for end-stage renal disease.
Alberto Zagury Anne Louise de Oliveira Jose Augusto Araujo Montalvão Regina Helena Leite Novaes Vinicius Martins de Sá Carlos Augusto Pinheiro de Moraes
J Bras Nefrol
August 2014
Introdution: Steroid resistant idiopathic nephrotic syndrome (SRINS) in children is one of the leading causes of progression to chronic kidney disease stage V (CKD V)/end stage renal disease (ESRD).
Objective: The aim of this retrospective study is to evaluate the efficacy of immunosuppressive drugs (IS) and to identify risk factors for progression to ESRD in this population.
Methods: Clinical and biochemical variables at presentation, early or late steroid resistance, histological pattern and response to cyclosporine A (CsA) and cyclophosfamide (CP) were reviewed in 136 children with SRINS.
Article Synopsis
- Cyclophosphamide (CP) has been used for over 40 years to treat children with steroid-dependent nephrotic syndrome (SDNS), specifically in those experiencing frequent relapses or steroid dependence.
- A study of 108 children aimed to find factors linked to prolonged and sustained remission (PSR+) of at least 5 years, revealing that the degree of steroid dependency greatly influenced remission outcomes.
- Children who relapsed while on prednisone doses exceeding 1.4 mg/kg showed poorer long-term remission rates, emphasizing the need to monitor prednisone dosage closely in relation to CP treatment effectiveness.