Publications by authors named "Carlos Atico Ariza"
The differentiation and proliferation of neural stem/progenitor cells (NPCs) depend on various in vivo environmental factors or cues, which may include an endogenous electrical field (EF), as observed during nervous system development and repair. In this study, we investigate the morphologic, phenotypic, and mitotic alterations of adult hippocampal NPCs that occur when exposed to two EFs of estimated endogenous strengths. NPCs treated with a 437 mV/mm direct current (DC) EF aligned perpendicularly to the EF vector and had a greater tendency to differentiate into neurons, but not into oligodendrocytes or astrocytes, compared to controls.
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- The study investigates how topography, extracellular matrix (ECM) proteins, and soluble factors together influence the differentiation of neural progenitor cells (NPCs).
- It was found that AHPCs grew on a specific ECM combination (ECL) and responded better to astrocyte-derived factors, resulting in a higher percentage of differentiation into oligodendrocytes compared to those grown on laminin alone.
- Micro-scale topography did not affect the differentiation of AHPCs under the conditions tested, highlighting the importance of ECM and soluble factors in NPC differentiation and proliferation.