Publications by authors named "Carlos Andres Valencia-Yepes"
Patterns of Antinuclear Antibodies in a New Variant of Endemic Pemphigus in El Bagre, Colombia, Colocalizing with Antigens against MIZAP, ARVCF, p0071, and Desmoplakins I and II.
Ana Maria Abreu-Velez Yulieth Alexandra Upegui-Zapata Carlos Andres Valencia-Yepes Eduardo Upegui-Quiceño Michael S Howard
J Appl Lab Med
October 2022
Article Synopsis
- A new variant of pemphigus foliaceus, named El Bagre-EPF, exhibits a distinctive pattern of antinuclear antibodies (ANAs) that was studied in 57 patients compared to 57 control subjects.
- The research revealed that 24% of El Bagre-EPF patients showed a unique ANA pattern, characterized by specific nuclear staining, which was statistically significantly different from the control group.
- This new ANA pattern was linked with certain proteins (MIZAP, ARVCF, p0071, and desmoplakins I-II) and also showed that 14% of patients exhibited classic homogeneous ANA patterns related to other specific autoantibodies.
Background: A new variant of endemic pemphigus foliaceus is present in El Bagre, Colombia, and surrounding municipalities (El Bagre-EPF) that affects the skin and in some presentations affects other organs with autoantibodies directed against cell junctions.
Methods: We studied 200 El Bagre-EPF patient perilesional skin biopsies, as well as 200 skin biopsies from normal controls in the endemic area.
Results: We observed blister extrusions of sebaceous glands or entire pilosebaceous units via the isthmus in 23% of the patients and not in the controls.