Developmental programming-ageing effects in muscle strength of obese rat offspring in a sex-dependent manner.

Maternal obesity programs the offspring to metabolic dysfunction. However, the effects of maternal obesity on skeletal muscle programming and ageing have been little explored. To determine if maternal obesity is a detriment to the progress of age-related muscle strength loss in the offspring (F), we evaluated the indicators of muscle strength, adiposity, and metabolism at young adult and senior adult ages of maternal obesity F1 (MOF) males and females from a high-fat diet-induced maternal obesity model in rat.