A graph theoretical approach for assessing bio-macromolecular complex structural stability.

Fast and proper assessment of bio macro-molecular complex structural rigidity as a measure of structural stability can be useful in systematic studies to predict molecular function, and can also enable the design of rapid scoring functions to rank automatically generated bio-molecular complexes. Based on the graph theoretical approach of Jacobs et al. [Jacobs DJ, Rader AJ, Kuhn LA, Thorpe MF (2001) Protein flexibility predictions using graph theory.

In vitro hydrolysis of blends from enantiomeric poly(lactide)s. 3. Homocrystallized and amorphous blend films.

Homocrystallized and amorphous enantiomeric blend films were prepared from the melt of high molecular weight poly(L-lactide) (PLLA) and poly(D-lactide) (PDLA) (1:1) by crystallization and quenching, respectively. A phosphate-buffered solution was used to investigate effects of homocrystallinity via in vitro hydrolysis as well as crystallization process during the hydrolysis, which was performed for a period of 24 months at 37 degrees C and pH 7.4.