Publications by authors named "Carlos Abrunhosa Tairum"
The emergence and re-emergence of bacterial strains resistant to multiple drugs represent a global health threat, and the search for novel biological targets is a worldwide concern. AhpC are enzymes involved in bacterial redox homeostasis by metabolizing diverse kinds of hydroperoxides. In pathogenic bacteria, AhpC are related to several functions, as some isoforms are characterized as virulence factors.
View Article and Find Full Text PDFFunctional and structural evaluation of the antileukaemic enzyme L-asparaginase II expressed at low temperature by different Escherichia coli strains.
Biotechnol Lett
November 2020
Acute lymphoblastic leukaemia (ALL) affects lymphoblastic cells and is the most common neoplasm during childhood. Among the pharmaceuticals used in the treatment protocols for ALL, Asparaginase (ASNase) from Escherichia coli (EcAII) is an essential biodrug. Meanwhile, the use of EcAII in neoplastic treatments causes several side effects, such as immunological reactions, hepatotoxicity, neurotoxicity, depression, and coagulation abnormalities.
View Article and Find Full Text PDFArticle Synopsis
- l-asparaginase is an enzyme used in cancer treatment, particularly for acute lymphoblastic leukemia and lymphosarcoma, by breaking down l-asparagine, leading to the death of cancer cells.
- Microbial production of l-asparaginase is gaining attention due to its cost-effectiveness and eco-friendliness, and this review focuses on various aspects of its production and characteristics.
- Key challenges include finding new enzyme sources, developing better ASNase variants, and enhancing production methods, with techniques like protein engineering and metabolic analysis being crucial for future advancements.