New Associations with the HIV Predisposing and Protective Alleles of the Human Leukocyte Antigen System in a Peruvian Population.

The accurate determination of an individual's unique human leukocyte antigen (HLA) allele holds important significance in evaluating the risk associated with autoimmune and infectious diseases, such as human immunodeficiency virus (HIV) infection. Several allelic variants within the HLA system have been linked to either increased protection or susceptibility in the context of infectious and autoimmune diseases. This study aimed to determine the frequency and association of HLA alleles between people living with HIV (PLHIV) as the case group and Peruvian individuals without HIV with high-risk behaviors of sexually transmitted diseases as the control group.

[Evaluation of COVID-19 vaccination programs in South America].

National vaccination programs against SARS-CoV2 in South America played an important role in the timely response to the COVID-19 pandemic, however, was an ethical approach capable of guaranteeing greater benefit to the population through vaccination being applied? To answer this question, my aim was to analyze the national vaccination programs of Argentina, Brazil, Chile, and Peru to identify the extent to which they aligned with the utilitarianism and prioritarianism oriented ethical approaches when assigning the vaccine against COVID-19. I start from the hypothesis that all the selected countries propose vaccination policies with possible prioritarian and/or utilitarian ethical approaches, however, those that align with prioritarianism manage to better adhere to the moral duties of social justice. To demonstrate my hypothesis, I have integrated the socio-economic information, analyzed the coverage strategies of each country and tried to frame them with the proposed ethical approaches, to finally present arguments for and against these approaches.

La pobreza extrema es prioridad: Un argumento sobre la distribución equitativa de la vacuna contra el COVID-19 en Perú.

La humanidad ya dispone de vacunas eficaces contra el COVID-19. En Perú se administraron 86 millones de dosis para cubrir la demanda de 33 millones de peruanos. Para ello, se ha priorizado la vacunación en grupos clave: personal de salud, sujetos con condiciones de salud preexistentes y mayores de 65 años.

Extreme poverty first: An argument on the equitable distribution of the COVID-19 vaccine in Peru.

Effective vaccines for COVID-19 are already available to humankind. In Peru, 86 million doses were administered to cover the demand for 33 million Peruvian people. Hence, vaccination has been prioritized in groups: health personnel, subjects with pre-existing health conditions and those over 65 years of age.

HIV treatment cascade in regions of Peru with the highest HIV prevalence.

Objectives: To describe the HIV treatment cascade and care continuum in regions of highest HIV prevalence in Peru.

Methods: An observational longitudinal study was carried out in 14 tertiary hospitals in Peru. These are the main hospitals that administer antiretroviral treatment (ART) in the regions that represent approximately 95% of reports of HIV/AIDS cases in Peru in 2013.

Social, Epidemiological, and Virological Characteristics from Peruvian Subjects Living with HIV-1/AIDS with Different Sexual Risk Behavior.

HIV-1 genetic diversity and resistance profile might change according to the risky sexual behavior of the host. To show this, we recruited 134 individuals between the years 2015 and 2017 identified as transgender women sex workers (TWSW,  = 73) and Heterosexual Military Officers (HET-MO,  = 61). After obtaining informed consent, we collected a blood sample to perform the HIV genotyping, CD4 cell count, and viral load.

Transmitted resistance in HIV-1 of patients from nine departments of Peru.

The main aim of this research is to identify the transmitted resistance (RT) of the Human Immunodeficiency Virus (HIV) in subjects from nine cities of Peru. For this, a descriptive and cross-sectional study was carried out in 135 adult subjects who agreed to participate through an informed consent. Blood samples were collected to perform the CD4 / CD8 cell count, viral load and HIV Genotyping.

New subtypes and genetic recombination in HIV type 1-infecting patients with highly active antiretroviral therapy in Peru (2008-2010).

HIV-1 subtype B is the most frequent strain in Peru. However, there is no available data about the genetic diversity of HIV-infected patients receiving highly active antiretroviral therapy (HAART) here. A group of 267 patients in the Peruvian National Treatment Program with virologic failure were tested for genotypic evidence of HIV drug resistance at the Instituto Nacional de Salud (INS) of Peru between March 2008 and December 2010.

Polymorphism, recombination, and mutations in HIV type 1 gag-infecting Peruvian male sex workers.

HIV genetic diversity in female sex workers (FSW) has been previously described in Peru; however this information is not yet available for male sex workers (MSW). Therefore, purified peripheral blood mononuclear cell DNA from 147 HIV-infected subjects identified as MSW and FSW was used to amplify a 460-bp fragment corresponding to the p24-p7 region of the gag gene. The PCR product was digested with restriction enzymes to identify genetic polymorphism.