Publications by authors named "Carlos A O Biagi Junior"
Article Synopsis
- Metabolic changes in pediatric diffuse midline glioma are influenced by the H3K27M histone mutation, which activates oncogenic pathways.
- The RAS pathway and ERK5 kinase are crucial for tumor growth in these gliomas, with ERK5 playing a key role in cell proliferation and glycolysis.
- Targeting the ERK5-PFKFB3 signaling axis with multi-targeted drugs could be an effective treatment strategy for patients with this type of cancer.
Article Synopsis
- Diffuse intrinsic pontine glioma (DIPG) is a serious brain tumor and is the most common cause of cancer deaths in kids.
- Scientists found that a protein called TIM-3 is present in both the tumor cells and nearby cells, which may help the tumor grow.
- By blocking TIM-3, they noticed that it helped some mice live longer and fight off the tumor, showing it could be a good target for new treatments for DIPG.
Our previous work using a melanoma progression model composed of melanocytic cells (melanocytes, primary and metastatic melanoma samples) demonstrated various deregulated genes, including a few known lncRNAs. Further analysis was conducted to discover novel lncRNAs associated with melanoma, and candidates were prioritized for their potential association with invasiveness or other metastasis-related processes. In this sense, we found the intergenic lncRNA U73166 (ENSG00000230454) and decided to explore its effects in melanoma.
View Article and Find Full Text PDFFilamentous fungus Purpureocillium lilacinum is an emerging pathogen that infects immunocompromised and immunocompetent individuals and is resistant to several azole molecules. Although azole resistance mechanisms are well studied in Aspergillus sp. and Candida sp.
View Article and Find Full Text PDFLipopolysaccharide triggers different transcriptional signatures in taurine and indicine cattle macrophages: Reactive oxygen species and potential outcomes to the development of immune response to infections.
PLoS One
January 2021
Macrophages are classified upon activation as classical activated M1 and M2 anti-inflammatory regulatory populations. This macrophage polarization is well characterized in humans and mice, but M1/M2 profile in cattle has been far less explored. Bos primigenius taurus (taurine) and Bos primigenius indicus (indicine) cattle display contrasting levels of resistance to infection and parasitic diseases such as C57BL/6J and Balb/c murine experimental models of parasite infection outcomes based on genetic background.
View Article and Find Full Text PDFArticle Synopsis
- * Key immune cells, like monocytes and macrophages, heavily populate the lungs of COVID-19 patients and undergo metabolic changes that support the virus's replication process.
- * The infection boosts mitochondrial ROS production, stabilizing a protein called HIF-1α, which promotes glycolysis and hampers T cell responses, suggesting that targeting HIF-1α could be a promising treatment strategy for COVID-19.
Aberrant expression of long non-coding RNAs (lncRNAs) has been detected in several types of cancer, including acute lymphoblastic leukemia (ALL), but lncRNA mapped on transcribed ultraconserved regions (T-UCRs) are little explored. The T-UCRs uc.112, uc.
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